Results 11 to 20 of about 2,803,576 (301)

Failure-aware kidney exchange

Proceedings of the fourteenth ACM conference on Electronic commerce, 2013
Algorithmic matches in fielded kidney exchanges do not typically result in an actual transplant. We address the problem of cycles and chains in proposed matches failing after the matching algorithm has committed to them. We show that failure-aware kidney exchange can significantly increase the expected number of lives saved (i) in theory, on random ...
John P. Dickerson, Ariel D. Procaccia, Tuomas Sandholm   +2 more
openaire   +3 more sources

Vitamin D and endothelial function in chronic kidney disease [PDF]

, 2014
PhDVitamin D deficiency in patients with chronic kidney disease, measured by reduced serum concentrations of 25 hydroxy vitamin D, is highly prevalent and associated with both endothelial dysfunction and an increased risk of cardiovascular disease ...
Dreyer, Gavin
core   +4 more sources

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

Physiological Reports, 2021
Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common pathological feature for various kinds of CKD.
Jinhua Miao, Jiewu Huang, Congwei Luo, Huiyun Ye, Xian Ling, Qinyu Wu, Weiwei Shen, Lili Zhou   +7 more
doaj   +1 more source

dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity

Disease Models & Mechanisms, 2021
Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng, Xizhen Hong, Qiuxia Fan, Liting Chen, Jing Li, Juan Deng, Siqiao Gong, Fan Fan Hou, Fujian Zhang   +8 more
doaj   +1 more source

Development and Validation of a Risk Score for Prediction of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure: A Prospective Cohort Study in China

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundAlthough several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early
Li Zhi Zhou, Xiao Bing Yang, Ying Guan, Xing Xu, Ming T. Tan, Fan Fan Hou, Ping Yan Chen   +6 more
doaj   +1 more source

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Nature Communications, 2022
Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically.
Qian Yuan, Qian Ren, Li Li, Huishi Tan, Meizhi Lu, Yuan Tian, Lu Huang, Boxin Zhao, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu   +11 more
doaj   +1 more source

A new outlook towards kidney injuries [PDF]

, 2012
Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Mahesh Satwekar, Abhijeet Satwekar
core   +1 more source

What is the real impact of acute kidney injury? [PDF]

, 2014
Background: Acute kidney injury (AKI) is a common clinical problem. Studies have documented the incidence of AKI in a variety of populations but to date we do not believe the real incidence of AKI has been accurately documented in a district general ...
Wheeler, Toby W.K., Toby WK Wheeler, Paul E Stevens, Michael Bedford, Michael Bedford, Bedford, Michael, Stevens, Paul E., Christopher KT Farmer, Farmer, Christopher K.   +8 more
core   +3 more sources

International consensus definitions of clinical trial outcomes for kidney failure:2020 [PDF]

, 2020
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney failure and key surrogates of progression to kidney failure ...
Tuttle, Katherine, Perkovic, Vlado, participant authors of the International Society of Nephrology’s, Shahinfar, Shahnaz, Jardine, Meg J., Malik, C, Damster, Sandrine, Jha, V, Damster, S, Agarwal, Rajiv, Thompson, Aliza M, Heerspink, Hiddo L., Thompson, AM, Perkovic, V, Thompson, Aliza M., Roberts, Glenda, Mann, JFE, Sunwold, Duane, Chong, K, Heerspink, HL, Shahinfar, S, Jardine, MJ, Vorster, H, Herrington, William G., de Zeeuw, D, Levin, A, Jha, Vivekanand, Sunwold, D, Roberts, Glenda V, Beaucage, Mary, Mann, Johannes F. E., Heerspink, Hiddo L, Herrington, William G, Warren, M, Warren, Madeleine, Agarwal, R, Beaucage, M, Herrington, WG, de Zeeuw, Dick; id_orcid, Mann, Johannes F E, Donner, Jo-Ann, Tuttle, KR, Vorster, Hans, Mahaffey, KW, Jardine, Meg J, Chong, Kate, participant authors of the International Society of Nephrology’s 1st International Consensus Meeting on Defining Kidney Failure in Clinical Trials,, Donner, J-A, Mahaffey, Kenneth W, Nangaku, M, Levin, Adeera, de Zeeuw, Dick, Roberts, GV, Tuttle, Katherine R., Nangaku, Masaomi, Mahaffey, Kenneth W., Malik, Charu   +56 more
core   +2 more sources

Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosisResearch in context

EBioMedicine, 2022
Summary: Background: The role of the IL6 family members in organ fibrosis, including renal interstitial fibrosis (TIF), has been widely explored. However, few studies have ever simultaneously examined them in the same cohort of patients.
Shihui Xu, Xiaobing Yang, Qingzhou Chen, Zhuoliang Liu, Ying Chen, Xiaotian Yao, An Xiao, Jianwei Tian, Liling Xie, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Xin Xu, Fanfan Hou, Jing Nie   +14 more
doaj   +1 more source