Results 21 to 30 of about 687,778 (313)

Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease

Renal Failure, 2023
Objectives Subfornical organ (SFO) is vital in chronic kidney disease (CKD) progression caused by high salt levels. The current study investigated the effects of high salt on phosphoproteomic changes in SFO in CKD rats.Methods 5/6 nephrectomized rats ...
Xin Wang, Huizhen Wang, Jiawen Li, Lanying Li, Yifan Wang, Aiqing Li   +5 more
doaj   +1 more source

Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol and HbA1c on cardiovascular and total mortality in patients with diabetes

Diabetology & Metabolic Syndrome, 2022
Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular ...
Panpan He, Xiaoqin Gan, Qimeng Wu, Ziliang Ye, Sisi Yang, Yanjun Zhang, Huan Li, Chun Zhou, Yuanyuan Zhang, Mengyi Liu, Xianhui Qin   +10 more
doaj   +1 more source

High-Salt Diet Accelerated the Decline of Residual Renal Function in Patients With Peritoneal Dialysis

Frontiers in Medicine, 2021
Objective: This study aims to investigate the relationship between dietary salt intake and residual renal function in peritoneal dialysis (PD) patients.Methods: The daily salt intake of the patients was calculated based on a 3 day dietary record.
Nirong Gong, Chun Zhou, Jianxia Hu, Xiaohong Zhong, Zhixiu Yi, Tingting Zhang, Cong Yang, Yanhong Lin, Jianwei Tian, Xianhui Qin, Liping Hu, Jianping Jiang, Jianping Jiang   +12 more
doaj   +1 more source

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

Physiological Reports, 2021
Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common pathological feature for various kinds of CKD.
Jinhua Miao, Jiewu Huang, Congwei Luo, Huiyun Ye, Xian Ling, Qinyu Wu, Weiwei Shen, Lili Zhou   +7 more
doaj   +1 more source

International consensus definitions of clinical trial outcomes for kidney failure:2020 [PDF]

, 2020
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney failure and key surrogates of progression to kidney failure ...
Tuttle, Katherine, Perkovic, Vlado, participant authors of the International Society of Nephrology’s, Shahinfar, Shahnaz, Jardine, Meg J., Malik, C, Damster, Sandrine, Jha, V, Damster, S, Agarwal, Rajiv, Thompson, Aliza M, Heerspink, Hiddo L., Thompson, AM, Perkovic, V, Thompson, Aliza M., Roberts, Glenda, Mann, JFE, Sunwold, Duane, Chong, K, Heerspink, HL, Shahinfar, S, Jardine, MJ, Vorster, H, Herrington, William G., de Zeeuw, D, Levin, A, Jha, Vivekanand, Sunwold, D, Roberts, Glenda V, Beaucage, Mary, Mann, Johannes F. E., Heerspink, Hiddo L, Herrington, William G, Warren, M, Warren, Madeleine, Agarwal, R, Beaucage, M, Herrington, WG, de Zeeuw, Dick; id_orcid, Mann, Johannes F E, Donner, Jo-Ann, Tuttle, KR, Vorster, Hans, Mahaffey, KW, Jardine, Meg J, Chong, Kate, participant authors of the International Society of Nephrology’s 1st International Consensus Meeting on Defining Kidney Failure in Clinical Trials,, Donner, J-A, Mahaffey, Kenneth W, Nangaku, M, Levin, Adeera, de Zeeuw, Dick, Roberts, GV, Tuttle, Katherine R., Nangaku, Masaomi, Mahaffey, Kenneth W., Malik, Charu   +56 more
core   +1 more source

A cross‐sectional study exploring cognitive impairment in kidney failure

, 2021
Background: Little is known of the prevalence or associated factors of cognitive impairment in people with kidney failure. Assessment of cognition is necessary to inform comprehension of healthcare information, aptitude for dialysis modality and informed
Theresa Green, Nicholas, P, Louise Purtell, Green, T, Pauline Nicholas, Purtell, L, Ann Bonner, Bonner, A   +7 more
core   +1 more source

Development and Validation of a Risk Score for Prediction of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure: A Prospective Cohort Study in China

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundAlthough several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early
Li Zhi Zhou, Xiao Bing Yang, Ying Guan, Xing Xu, Ming T. Tan, Fan Fan Hou, Ping Yan Chen   +6 more
doaj   +1 more source

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Nature Communications, 2022
Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically.
Qian Yuan, Qian Ren, Li Li, Huishi Tan, Meizhi Lu, Yuan Tian, Lu Huang, Boxin Zhao, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu   +11 more
doaj   +1 more source

dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity

Disease Models & Mechanisms, 2021
Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng, Xizhen Hong, Qiuxia Fan, Liting Chen, Jing Li, Juan Deng, Siqiao Gong, Fan Fan Hou, Fujian Zhang   +8 more
doaj   +1 more source

What is the real impact of acute kidney injury? [PDF]

, 2014
Background: Acute kidney injury (AKI) is a common clinical problem. Studies have documented the incidence of AKI in a variety of populations but to date we do not believe the real incidence of AKI has been accurately documented in a district general ...
Wheeler, Toby W.K., Toby WK Wheeler, Paul E Stevens, Michael Bedford, Michael Bedford, Bedford, Michael, Stevens, Paul E., Christopher KT Farmer, Farmer, Christopher K.   +8 more
core   +1 more source