Results 21 to 30 of about 5,063,263 (354)

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells

open access: yesPhysiological Reports, 2021
Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common pathological feature for various kinds of CKD.
Jinhua Miao   +7 more
doaj   +1 more source

Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes.

open access: yesKidney International, 2022
This study applies a large proteomics panel to search for new circulating biomarkers associated with progression to kidney failure in individuals with diabetic kidney disease.
Hiroki Kobayashi   +14 more
semanticscholar   +1 more source

Development and Validation of a Risk Score for Prediction of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure: A Prospective Cohort Study in China

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundAlthough several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early
Li Zhi Zhou   +6 more
doaj   +1 more source

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

open access: yesNature Communications, 2022
Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically.
Qian Yuan   +11 more
doaj   +1 more source

dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity

open access: yesDisease Models & Mechanisms, 2021
Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng   +8 more
doaj   +1 more source

Kidney Transplant Failure [PDF]

open access: yesClinical Journal of the American Society of Nephrology, 2014
Kidney transplant failure is an important cause of dialysis initiation in the United States. In 2011, this group represented 4.7% of patients new to dialysis, a 30% increase in the number of patients initiating dialysis after transplant failure since 2000 ([1][1]).
openaire   +2 more sources

Classification of Uremic Toxins and Their Role in Kidney Failure.

open access: yesAmerican Society of Nephrology. Clinical Journal, 2021
Advances in our understanding of uremic retention solutes, as well as improvements in hemodialysis membranes and other techniques designed to remove uremic retention solutes, offer opportunities to readdress the definition and classification of uremic ...
M. Rosner   +15 more
semanticscholar   +1 more source

High-Salt Diet Accelerated the Decline of Residual Renal Function in Patients With Peritoneal Dialysis

open access: yesFrontiers in Medicine, 2021
Objective: This study aims to investigate the relationship between dietary salt intake and residual renal function in peritoneal dialysis (PD) patients.Methods: The daily salt intake of the patients was calculated based on a 3 day dietary record.
Nirong Gong   +12 more
doaj   +1 more source

Dose of colistin. a work in progress? [PDF]

open access: yes, 2015
We thank Rashid and colleagues [1] and Honoré and colleagues [2] for their comments regarding our article on risk factors for acute kidney injury in pa- tients receiving colistin or other nephrotoxic antimi- crobials [3].
Antonelli, M.   +3 more
core   +1 more source

Kidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD

open access: yesJournal of the American Society of Nephrology, 2021
Visual Abstract Significance Statement Most kidney failure prediction models have been developed and validated in cohorts of patients with a wide range of disease severity, without accounting for the competing risk of death.
Chava L. Ramspek   +13 more
semanticscholar   +1 more source

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