Results 91 to 100 of about 11,650,232 (283)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The Health of Children and Young People with Chronic Conditions and Disabilities in the South Island 2016 [PDF]

, 2017
Chronic conditions and disabilities often affect people for life. Having a good quality of life and flourishing to your best ability is dependent, at least in part, on what happened as you were growing up.
Morris, Simon, Simpson, Jean, Adams, Judith, Gallagher, Sarah, Duncanson, Mavis, Oben, Glenda, Wicken, Andrew   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Health of Children and Young People with Chronic Conditions and Disabilities in the Midland Region 2016 [PDF]

, 2017
Chronic conditions and disabilities often affect people for life. Having a good quality of life and flourishing to your best ability is dependent, at least in part, on what happened as you were growing up.
Morris, Simon, Simpson, Jean, Adams, Judith, Gallagher, Sarah, Duncanson, Mavis, Oben, Glenda, Wicken, Andrew   +6 more
core   +1 more source

Expert Patient Programme Catalonia: a person-centered community perspective

International Journal of Integrated Care, 2015
Paloma Amil Bujan, Assumpció González Mestre, Carles Blay Pueyo, Albert Ledesma Castelltort, Joan Carles Contel Segura, Carles Constante Beitia   +5 more
doaj   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Health of Children and Young People with Chronic Conditions and Disabilities in the Hawke's Bay 2016 [PDF]

, 2017
Chronic conditions and disabilities often affect people for life. Having a good quality of life and flourishing to your best ability is dependent, at least in part, on what happened as you were growing up.
Morris, Simon, Simpson, Jean, Adams, Judith, Gallagher, Sarah, Duncanson, Mavis, Oben, Glenda, Wicken, Andrew   +6 more
core   +1 more source

Development and Validation of a Culturally Adapted Patient‐Reported Experience Measure for Diabetes Care in Thailand: Mixed‐Methods Study

Health Expectations
Background Patient‐centred care is essential for managing Type 2 diabetes, as it relies on understanding patients’ experiences and perspectives. However, in Thailand, no culturally adapted patient‐reported experience measure (PREM) exists to capture ...
Soe Sandi Tint, Nida Buawangpong, Wichuda Jiraporncharoen, Myo Zin Oo, Nutchar Wiwatkunupakarn, Kittipan Rerkasem, Kanokwan Kulprachakarn, Hataichanok Chuljerm, Timothy E. O'Brien, Rohini Mathur, Petch Rawdaree, Chaisiri Angkurawaranon   +11 more
doaj   +1 more source

Implementing and evaluating integrated care models for non-communicable diseases in fragile and humanitarian settings

Journal of Migration and Health
In this commentary, we advocate for the wider implementation of integrated care models for NCDs within humanitarian preparedness, response, and resilience efforts.
Lavanya Vijayasingham, Éimhín Ansbro, Carla Zmeter, Linda Abou Abbas, Benjamin Schmid, Leah Sanga, Lars Bruun Larsen, Sigiriya Aebischer Perone, Pablo Perel   +8 more
doaj   +1 more source