Results 101 to 110 of about 11,158,031 (291)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Northern Territory annual report 2012 - 2013

, 2020
The aim of the strategy is: ?To improve the health and wellbeing of all Territorians by reducing the incidence and impact of chronic conditions.? This strategy is a continuation of the past work of health leaders and reinforces the need for strategic ...
Chronic Conditions Strategy Unit
core  

Bibliometric analysis of scholarly publications related to family medicine in Thailand

Heliyon
Background: Family medicine has been recognized as a medical specialty in Thailand. However, there is a lack of information about scholarly publications.
Nutchar Wiwatkunupakarn, Sasiwimon Moonkayaow, Abigail Morse, Nida Buawangpong, Suphawita Pliannuom, Soe Sandi Tint, Apichai Wattanapisit, Chaisiri Angkurawaranon   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Winners and losers in the global trade in food

The Lancet Global Health, 2020
Martin McKee, May van Schalkwyk
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Perspectives of patients, caregivers, and healthcare providers on how the Heart@Home mobile application improves self-management in heart failure care: A qualitative study

Internet Interventions
Objectives: This study aims to investigate the perspectives of patients, caregivers, and healthcare providers on how the Heart@Home application improves self-management following a two-week period of usage and how to improve the application for further ...
Alicha Chumintrachark, Kanokporn Pinyopornpanish, Chanchanok Aramrat, Chutamas Pairoj, Nida Buawangpong, Suphawita Pliannuom, Sarapee Seesopon, Mesaya Khangtanyakit, Nopakoon Nantsupawat, Wichuda Jiraporncharoen, Chaisiri Angkurawaranon, Arintaya Phrommintikul   +11 more
doaj   +1 more source