Results 121 to 130 of about 3,488,730 (309)

Expert Patient Programme Catalonia: a person-centered community perspective

International Journal of Integrated Care, 2015
Paloma Amil Bujan, Assumpció González Mestre, Carles Blay Pueyo, Albert Ledesma Castelltort, Joan Carles Contel Segura, Carles Constante Beitia   +5 more
doaj   +3 more sources

Implementing and evaluating integrated care models for non-communicable diseases in fragile and humanitarian settings

Journal of Migration and Health
In this commentary, we advocate for the wider implementation of integrated care models for NCDs within humanitarian preparedness, response, and resilience efforts.
Lavanya Vijayasingham, Éimhín Ansbro, Carla Zmeter, Linda Abou Abbas, Benjamin Schmid, Leah Sanga, Lars Bruun Larsen, Sigiriya Aebischer Perone, Pablo Perel   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development and Validation of a Culturally Adapted Patient‐Reported Experience Measure for Diabetes Care in Thailand: Mixed‐Methods Study

Health Expectations
Background Patient‐centred care is essential for managing Type 2 diabetes, as it relies on understanding patients’ experiences and perspectives. However, in Thailand, no culturally adapted patient‐reported experience measure (PREM) exists to capture ...
Soe Sandi Tint, Nida Buawangpong, Wichuda Jiraporncharoen, Myo Zin Oo, Nutchar Wiwatkunupakarn, Kittipan Rerkasem, Kanokwan Kulprachakarn, Hataichanok Chuljerm, Timothy E. O'Brien, Rohini Mathur, Petch Rawdaree, Chaisiri Angkurawaranon   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Understanding the Twentieth Century Decline in Chronic Conditions Among Older Men [PDF]

I use a sample of Union Army veterans to trace the impact of a high infant mortality rate in area of enlistment, such infectious disease as acute respiratory infections, measles, typhoid fever, tuberculosis, rheumatic fever, diarrhea, and malaria while ...
Dora L. Costa
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

More Nonelderly Americans Face Problems Affording Prescription Drugs [PDF]

, 2009
Analyzes 2003-07 trends in unmet prescription drug needs among Americans under age 65 by insurance status and type of coverage, income level, and the presence of chronic conditions.
James D. Reschovsky, Laurie E. Felland
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source