Results 171 to 180 of about 11,650,232 (283)

Chronic conditions and aortic disease risk: a prospective cohort study with predictive and etiological analyses. [PDF]

Nat Commun
Yu L, Lu P, Yang M, Wang X, Liu Q, Long P, Fang ZM, Zhang Z, Zhao J, Xiang Q, Yu C, Du H, Yang L, Chen Y, Chen Z, Lv J, Li L, Sun D, Liu W, Yi X, Jiang DS.   +20 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Comparing Quality of Life in Smell and Taste Disorders With Other Chronic Conditions-A Narrative Review. [PDF]

Clin Otolaryngol
Glibbery N, Turner D, Boak D, Philpott C.   +3 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Empowering youth with chronic conditions: enhancing sexual and reproductive health through evidence and engagement - protocol for a co-design approach. [PDF]

BMJ Open
Meherali S, Nisa S, Lebeuf S, Hartling L, Kassiri J, Khoury M, Kirkpatrick L, Levy D, Norman WV, Norozi K, Scott S, Shahil-Feroz A, Steiman A, Vandermorris A.   +13 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Multidomain Outcomes of a Digital Self-Management Program in Rural Adults With Chronic Conditions: Single-Arm Prospective Interventional Study. [PDF]

JMIR Mhealth Uhealth
Smith NK, Ilie G, MacDonald C, Langley JRB, Rutledge RDH.   +4 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Assessing Quality of Life and Associated Factors Among Caregivers of Children With Chronic Conditions at Tamale Teaching Hospital: A Cross-Sectional Study. [PDF]

Health Sci Rep
Iddrisu R, Alhassan AR, Kaleem-Ahmed M, Adjeso YN.   +3 more
europepmc   +1 more source