Results 181 to 190 of about 11,158,031 (291)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Unravelling the diversity of pacing behaviours in adults with chronic conditions: a cross-sectional study. [PDF]

BMJ Open
Barakou I, Seves BL, Abonie U, Finch T, Hackett K, Hettinga F.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Complex Chronic Conditions in the PICU: Single-Center Retrospective Study in Central-Southern China, 2020-2025. [PDF]

Pediatr Crit Care Med
Li X, Yan H, Li X, Zhang X, Huang J, Gan J, Luo T, Wang X, Xie L, Yang Y, Zou H, Xiao Z.   +11 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Effect of a digital intervention on mental health symptoms in adults with chronic conditions: A three-arm randomized controlled trial. [PDF]

PLoS Med
Johnson E, Hyde A, Corrick S, Isley S, Wright G, Ezekowitz J, Zheng Y, Lee-Baggley D, Spiers J, Spence JC, McNeely ML, Thompson S, Ismond K, Tymchuk S, Tandon P.   +14 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Loneliness, Chronic Conditions, and Healthcare Engagement in Japan: A Nationwide Cross-Sectional Study. [PDF]

JMA J
Ito H, Okaya S, Watanabe T, Zheng YF, Shimojo N, Kawano S, Tabuchi T.   +6 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The COCCOS study: A protocol for a multicentric quasi-experimental study of a healthcare transition program for young people with chronic conditions. [PDF]

PLoS One
Van Wilder L, Janssens N, Van Hoorenbeeck K, Vanden Wyngaert K, Goossens E, De Smedt D.   +5 more
europepmc   +1 more source