Results 61 to 70 of about 2,952,772 (291)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
Anderson, George, Leonard, B, Cai Song, Goehler, Lisa, Gałecki, Piotr, Michael Berk, Michael Maes, Berk, M, Berk, Michael, Maes, Michael, Song, Cai, Leonard, B., Anderson, G, Anderson, G., Leonard, Brian, Maes, M., Piotr Gałecki, Goehler, L., Gałecki, P., Berk, M., Goehler, L, Brian Leonard, Song, C, Gałecki, P, Lisa Goehler, George Anderson, Maes, M, Song, C., Goehler Lisa, Song Cai, Anderson George, Maes Michael, Berk Michael, Gałecki Piotr, Leonard Brian   +34 more
core   +2 more sources

Self-management strategies and care needs of patients with persistent depressive disorder and their informal caregivers: a multi-perspectives qualitative interview study

Frontiers in Psychiatry
IntroductionWhen patients with persistent depressive disorder (PDD) respond insufficiently to available evidence-based treatments, depression treatment guidelines recommend psychiatric rehabilitation through self-management.
Ericka C. Solis, Ingrid V. E. Carlier, Noëlle G. A. Kamminga, Noëlle G. A. Kamminga, Albert M. van Hemert   +4 more
doaj   +1 more source

Depression and Quality of Life among the Chronic Kidney Disease Patients

Journal of Nepal Health Research Council, 2020
Background: Depression and other mental illness are very common among chronic kidney disease and also Quality of life has been found significantly impaired in chronic kidney disease.
Dipak Kunwar, Rajyashree Kunwar, Barsha Shrestha, Richa Amatya, Ajay Risal   +4 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Perspectives of patients with depression and chronic pain about bone health after a fragility fracture: A qualitative study

Health Expectations, 2022
Background Compromised bone health is often associated with depression and chronic pain. Objective To examine: (1) the experience of existing depression and chronic nonfracture pain in patients with a fragility fracture; and (2) the effects of the ...
Joanna E. M. Sale, Monique Gignac, Lucy Frankel, Stephen Thielke, Earl Bogoch, Victoria Elliot‐Gibson, Gillian Hawker, Larry Funnell   +7 more
doaj   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Complex interaction of sensory and motor signs and symptoms in chronic CRPS. [PDF]

, 2011
Spontaneous pain, hyperalgesia as well as sensory abnormalities, autonomic, trophic, and motor disturbances are key features of Complex Regional Pain Syndrome (CRPS).
Lauchart, Meike, Magerl, Walter, Antje Beyer, Kaufhold, Wibke, Schelling, Gustav, Volker Huge, Meike Lauchart, Beyer, Antje, Shahnaz Christina Azad, Gustav Schelling, Huge, Volker, Patrick Moehnle, Möhnle, Patrick, Azad, Shahnaz Christina, Wibke Kaufhold, Walter Magerl   +15 more
core   +2 more sources

Restless legs syndrome, anxiety, and depression in phlebology practice

Veins and Lymphatics, 2020
The aim was to analyze the prevalence and overlapping of chronic venous disorders, restless legs syndrome, anxiety and depressive conditions. There were 582 subjects enroll; 450 (77.5%) women and 132 (22.5%) men (mean age 45.0).
Konstantin Mazayshvili, Kseniya Kiyan, Alexey Sukhanov, Yury Gustelev   +3 more
doaj   +1 more source