Results 91 to 100 of about 8,726,957 (297)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Chronic diseases in America [PDF]

6 IN 10 Adults in the US have a chronic disease4 IN 10 Adults in the US have two or moreTHE LEADING CAUSES OF DEATH AND DISABILITY and Leading Drivers of the Nation\u2019s $3.3 Trillion in Annual Health Care Costswww.cdc.gov/chronicdiseasePublication ...

core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Efficient organized colorectal cancer screening in Shenzhen: a microsimulation modelling study

BMC Public Health
Background Colorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiple screening strategies. The study aimed to identify the efficient
Minmin Zhu, Xuan Zhong, Tong Liao, Xiaolin Peng, Lin Lei, Ji Peng, Yong Cao   +6 more
doaj   +1 more source

Health economic evaluation of community-based diabetic retinopathy screening among type 2 diabetes mellitus patients in Shenzhen, China: a Markov model simulation study

Zhongguo gonggong weisheng
ObjectiveTo conduct a health economic evaluation of a community-based screening strategy for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Shenzhen, Guangdong Province, and to provide evidence for implementation of this ...
Ziyang ZHANG, Chongwei ZHANG, Yali LIN, Jingwen YU, Xiaobing WU   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

At a glance 2015 : National Center for Chronic Disease Prevention and Health Promotion [PDF]

Chronic diseases are common, costly, and debilitating, but they can often be prevented. By choosing healthy behaviors\u2014like avoiding tobacco, eating healthy food and beverages, and getting regular physical activity\u2014people can reduce their ...

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Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Status and associated factors of food and nutrition literacy among young adults aged 15–44 years in Shenzhen City, China

Frontiers in Public Health
BackgroundFood and nutrition literacy (FNL) plays an important role in young adults’ dietary habits and nutrition. This study aimed to investigate FNL status and its associated factors among young adults aged 15–44 years in Shenzhen.MethodsA cross ...
Li Zhixue, Xu Ying, Liu Zheng, Ma Yan, Guo Yanfang, Wang Dewang, Yu Weijun, Zhao Rencheng, Yuan Qing, Xu Meihong   +9 more
doaj   +1 more source