Results 91 to 100 of about 9,268,217 (299)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Efficient organized colorectal cancer screening in Shenzhen: a microsimulation modelling study

BMC Public Health
Background Colorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiple screening strategies. The study aimed to identify the efficient
Minmin Zhu, Xuan Zhong, Tong Liao, Xiaolin Peng, Lin Lei, Ji Peng, Yong Cao   +6 more
doaj   +1 more source

Patients’ Experiences of the Western HealthLinks Integrated Care Chronic Illness Management Program: A Prospective Mixed-Methods Observational Cohort Study

International Journal of Integrated Care
Introduction: Western HealthLinks, an integrated care chronic illness management program, supported patients with chronic and complex conditions to stay well at home after hospital discharge.
Julia L. Jones, Kirsty Barnes, Catherine Grant, Jason Plant, Natalie G. Lumsden, Koen Simons, Edward D. Janus, Craig L. Nelson, Ann Allenby   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Health economic evaluation of community-based diabetic retinopathy screening among type 2 diabetes mellitus patients in Shenzhen, China: a Markov model simulation study

Zhongguo gonggong weisheng
ObjectiveTo conduct a health economic evaluation of a community-based screening strategy for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Shenzhen, Guangdong Province, and to provide evidence for implementation of this ...
Ziyang ZHANG, Chongwei ZHANG, Yali LIN, Jingwen YU, Xiaobing WU   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

GIS express for chronic disease ; v. 1, issue 1, May 15, 2018

We are excited to present the inaugural issue of the GIS Express for Chronic Disease. This newsletter is designed to keep you up-to-date about GIS-related information that is readily available from CDC\u2019s Division for Heart Disease and Stroke ...

core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

GIS Hallmarks : Maximizing the benefits of GIS for chronic disease prevention and health promotion. [PDF]

Chronic disease prevention leaders recognize the tremendous benefits of using geographic information systems (GIS) for a wide range of public health goals \u2013 advancing health equity, documenting the burden of disease, enhancing the efficiency of ...

core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source