Results 81 to 90 of about 8,726,957 (297)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of CD4 count on Mycobacterium tuberculosis infection rates in people living with HIV: a comparative study in prison and community

Scientific Reports
To evaluate the impact of the CD4 count on ESAT6-CFP10 (EC) skin test, QuantiFERON-TB Gold In-tube test (QFT) and tuberculin skin test (TST) in a large prison and communities in Jiangsu Province among people living with HIV (PLHIV).
Peng Lu, Yilin Lian, Zhongqi Li, Kai Wu, Zhuping Xu, Hao Xue, Jincheng Li, Xing Zhang, Rong Wang, Xiaoyan Ding, Jingjing Pan, Hui Ding, Qiao Liu, Limei Zhu, Haitao Yang   +14 more
doaj   +1 more source

Validating the use of veterans affairs tobacco health factors for assessing change in smoking status: accuracy, availability, and approach

BMC Medical Research Methodology, 2018
Background Accurate smoking status is key for research purposes, but can be costly and difficult to measure. Within the Veteran’s Health Administration (VA), smoking status is recorded as part of routine care as “health factors” (HF)—fields that ...
Anne C. Melzer, Erika A. Pinsker, Barbara Clothier, Siamak Noorbaloochi, Diana J. Burgess, Elisheva R. Danan, Steven S. Fu   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Rehospitalization risk in community-dwelling schizophrenia patients receiving paliperidone palmitate: a retrospective cohort study in urban China

BMC Psychiatry
Background While long-acting injectable paliperidone palmitate (PP-LAI) improves treatment adherence in schizophrenia, rehospitalization risks persist under community management.
Cheng-Feng Liu, Jiao-Lian Yuan, Juan Cheng, Jing-Lu Lu, Wei-Yun Wang, Shao-Ling Zhong, Chu-Hong Lu, Li Qing, Ying Xu, Liang Zhou, Yan-Fang Guo   +10 more
doaj   +1 more source

Social determinants of breast cancer in the Caribbean: a systematic review

International Journal for Equity in Health, 2017
Background Breast cancer is the leading cause of cancer deaths among women in the Caribbean and accounts for >1 million disability adjusted life years. Little is known about the social inequalities of this disease in the Caribbean.
Catherine R. Brown, Ian R. Hambleton, Shawn M. Hercules, Miriam Alvarado, Nigel Unwin, Madhuvanti M. Murphy, E. Nigel Harris, Rainford Wilks, Marlene MacLeish, Louis Sullivan, Natasha Sobers-Grannum, The U.S. Caribbean Alliance for Health Disparities Research Group (USCAHDR)   +11 more
doaj   +1 more source

ANEMIA OF CHRONIC DISEASE

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2015
В лекции рассматривается одна из самых распространенных форм анемий, которая развивается как воспалительная реакция в ответ на системное заболевание. Приведены данные об основных причинах возникновения, патогенезе, клинических проявлениях анемии, а также основные подходы к диагностике и лечению этого заболевания.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source