Results 121 to 130 of about 5,016,105 (350)

Chronic Lyme Disease [PDF]

Infectious Disease Clinics of North America, 2015
Chronic Lyme disease is a poorly defined diagnosis that is usually given to patients with prolonged, unexplained symptoms or with alternative medical diagnoses. Data do not support the proposition that chronic, treatment-refractory infection with Borrelia burgdorferi is responsible for the many conditions that get labeled as chronic Lyme disease ...
openaire   +2 more sources

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Efficient organized colorectal cancer screening in Shenzhen: a microsimulation modelling study

BMC Public Health
Background Colorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiple screening strategies. The study aimed to identify the efficient
Minmin Zhu, Xuan Zhong, Tong Liao, Xiaolin Peng, Lin Lei, Ji Peng, Yong Cao   +6 more
doaj   +1 more source

Health economic evaluation of community-based diabetic retinopathy screening among type 2 diabetes mellitus patients in Shenzhen, China: a Markov model simulation study

Zhongguo gonggong weisheng
ObjectiveTo conduct a health economic evaluation of a community-based screening strategy for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Shenzhen, Guangdong Province, and to provide evidence for implementation of this ...
Ziyang ZHANG, Chongwei ZHANG, Yali LIN, Jingwen YU, Xiaobing WU   +4 more
doaj   +1 more source

Prevalence and correlates of chronic diseases in an elderly population: A community-based survey in Haikou [PDF]

, 2018
Chanjuan Zhao, Li Ping Wong, Qing Zhu, Hao Yang   +3 more
openalex   +1 more source

Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

, 2022
Russell G. Buhr, Igor Barjaktarević, P. Miguel Quibrera, Lori A. Bateman, Eugene R. Bleecker, David Couper, Jeffrey L. Curtis, Brett A. Dolezal, MeiLan K. Han, Nadia N. Hansel, Jerry A. Krishnan, Fernando J. Martínez, William McKleroy, Robert Paine, Stephen I. Rennard, Donald P. Tashkin, Prescott G. Woodruff, Richard E. Kanner, Christopher B. Cooper, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, R. Graham Barr, Surya P. Bhatt, Richard C. Boucher, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Gerard J. Criner, Ronald G. Crystal, Claire M. Doerschuk, Mark T. Dransfield, Brad Drummond, Christine M. Freeman, Craig J. Galbán, Annette T. Hastie, Eric A. Hoffman, Yvonne J. Huang, Robert J. Kaner, Eric C. Kleerup, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Laura M. Paulin, Stephen P. Peters, Cheryl Pirozzi, Nirupama Putcha, Elizabeth C. Oelsner, Emily S. Wan, Victor E. Ortega, Sanjeev Raman, J. Michael Wells, Robert A. Wise   +54 more
openalex   +2 more sources

Managing chronic disease

BMJ, 1999
Rapid improvements in health and longevity are dramatically changing the burden of illness throughout the world. In developed countries changes in lifestyle and improvements in the treatment of major causes of mortality have aged the population and increased the prevalence of chronic diseases.
R M, Davis, E H, Wagner, T, Groves
openaire   +3 more sources

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care [PDF]

, 2018
Shankar Kumar, Simon de Lusignan, Andrew McGovern, Ana Correa, Mariya Hriskova, Piers Gatenby, Simon Jones, David Goldsmith, A. John Camm   +8 more
openalex   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source