Results 131 to 140 of about 8,726,957 (297)
Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]
, 2012 The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P. +4 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The purpose of the Practitioner's Guide for Advancing Health Equity: Community Strategies for Preventing Chronic Disease is to help address disparities in chronic disease health outcomes.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Centers for Disease Control and Prevention (CDC) Arthritis Program has developed the 1-2-3 Approach to Provider Outreach to help raise awareness among primary care practices of the benefits of self-management education and physical activity ...
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Achieving impact : state successes in improving school nutrition, physical education, physical activity, and the management of chronic health conditions in schools [PDF]
The Centers for Disease Control and Prevention (CDC) funds states nationwide to reduce the risk factors associated with childhood and adult obesity, diabetes, heart disease, and stroke through a cooperative agreement entitled State Public Health Actions ...
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Physical activity prevents chronic disease [PDF]
Regular physical activity helps improve your overall health, fitness, and quality of life.It also helps reduce your risk of these chronic conditions and manage them better:\u2022 Heart disease\u2022 Type 2 diabetes\u2022 Many type of cancer\u2022 ...
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Vitamin D and endothelial function in chronic kidney disease [PDF]
, 2014 PhDVitamin D deficiency in patients with chronic kidney disease, measured by reduced serum concentrations of 25 hydroxy vitamin D, is highly prevalent and associated with both endothelial dysfunction and an increased risk of cardiovascular disease ...
Dreyer, Gavin
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