Results 151 to 160 of about 8,726,957 (297)

Partnering with pharmacists in the prevention and control of chronic diseases [PDF]

New ways to expand team-based health care are needed to protect the health of Americans. Many chronic diseases, which are increasing with the aging U.S. population, are preventable or manageable.

core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Anemia of Chronic Disease: Pathophysiology, Diagnosis and Management. [PDF]

Hematol Rep
Abbotts K, Sriskandarajah P.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Self-as-doer and health promotion for patients with chronic disease. [PDF]

J Educ Health Promot
Pishjoo A, Tedadi Y, Tol A, Sadeghi R, Brouwer AM.   +4 more
europepmc   +1 more source

Policy evidence assessment report : community health worker policy components [PDF]

Policy Evidence Assessment Reports summarize the evidence bases for components of chronic disease policy. Evidencebased policy can be used to prevent, control, and improve the outcomes of chronic disease, but the strength of the evidence for many ...

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Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Standardized chronic disease management reduces comorbidity risk in China. [PDF]

Nat Commun
Liu L, Li Y, Huang Q, Ke L, Feng G, Yin B, Xiang W, Wang M, Zhong J, Liu Y, Tian Q, Wu L, He X, Zeng H, Liang W, Gu K, Zhu J, Di Q.   +17 more
europepmc   +1 more source

Chronic disease . . . the public health challenge of the 21st century [PDF]

"The United States spends significantly more on health care than any other nation. In 2006, our health care expenditure was over $7,000 per person, more than twice the average of 29 other developed countries.

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Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source