Results 161 to 170 of about 8,726,957 (297)

Flourishing in chronic disease care: a narrative review and proposed conceptual framework. [PDF]

Front Psychol
Feng Z, Yang Q.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The multisystem impact of perimenopausal hormonal fluctuations on chronic disease risk. [PDF]

Front Endocrinol (Lausanne)
Luo L, Li L, Wang X, Bai W.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Gender Divergence in COPD Phenotypes and Narrowing Urban–Rural Diagnostic Gaps: A Surveillance Study in Chongqing, China, 2020–2024

International Journal of COPD
Qiang Tan,* Yang Gao,* Xiaoyan Lv, Yan Jiao, Jian Lian, Xianbin Ding Institute of Chronic and Non‑communicable Disease Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing, 400042, People’s Republic of ...
Tan Q, Gao Y, Lv X, Jiao Y, Lian J, Ding X   +5 more
doaj  

Sarcoidosis data-driven patient trajectories and predictors of chronic disease. [PDF]

Respir Res
Rossides M, Kullberg S, Darlington P, Eklund A, Arkema EV.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Danish Chronic Disease Cohort: using digital footprints to identify chronic disease patterns. [PDF]

Eur J Epidemiol
Taber A, Flyckt RNH, Henriksen MHB, Innos K, Nystad W, Kjerpeseth LJ, Sandgren BL, Varnum C, Pedersen MRV, Johansen C, Hansen TF, Brasen CL.   +11 more
europepmc   +1 more source

Addressing chronic disease through community health workers : a policy and systems-level approach : a policy brief on community health workers. 2nd edition, April 2015

This document provides guidance and resources for implementing recommendations to integrate community health workers (CHWs) into community-based efforts to prevent chronic disease.

core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source