Results 221 to 230 of about 3,334,013 (297)

Application of chatbots in chronic disease management: A scoping review. [PDF]

Digit Health
Hou J, Lin S, Teng P, Han Y, Luo Y, He G.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Arsenic Exposure Reduction and Chronic Disease Mortality. [PDF]

JAMA
Wu F, van Geen A, Graziano J, Ahmed KM, Liu M, Argos M, Parvez F, Choudhury I, Slavkovich VN, Ellis T, Islam T, Ahmed A, Kibriya MG, Jasmine F, Shahriar MH, Hasan R, Shima SA, Sarwar G, Navas-Acien A, Ahsan H, Chen Y.   +20 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Health Information Adoption Among Patients With Chronic Disease in China: Qualitative Interview Study of Patient-Platform Coshaping. [PDF]

J Med Internet Res
Huang L, Duan G, Tang J, He P.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

A medication literacy instrument for older chronic disease patients in China: development and validation. [PDF]

BMC Geriatr
Zhou B, Zhao Z, Wu M, Li X.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice. [PDF]

Nat Microbiol
Zarrella KM, Sheridan RM, Ware BC, Davenport BJ, da Silva MOL, Vyshenska D, Martin AU, May NA, Fish ER, Weiskopf D, Hesselberth JR, Streblow DN, Greninger AL, Morrison TE.   +13 more
europepmc   +1 more source