Results 51 to 60 of about 3,185,529 (387)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The Natural History of Hepatitis C Virus Infection and Disease in the Era of Curative Therapy with Direct-Acting Antivirals

Viruses
The availability of highly effective direct-acting antivirals (DAAs) that cure individuals infected with HCV has changed completely the natural history of HCV infection and chronic hepatitis C.
Maurizia Rossana Brunetto, Ferruccio Bonino   +1 more
doaj   +1 more source

Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.

Gastroenterology, 2005
BACKGROUND AND AIMS Transient elastography (FibroScan; Echosens, Paris, France) is a novel, noninvasive, and rapid bedside method to assess liver fibrosis by measuring liver stiffness.
L. Castéra, J. Vergniol, J. Foucher, B. le Bail, E. Chanteloup, M. Haaser, M. Darriet, P. Couzigou, V. de Lédinghen   +8 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Emerging Microbes and Infections
Type I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection.
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Costs of Treatment, Follow-Up, and Complications of Chronic Hepatitis B and Hepatitis C Infections

Balkan Medical Journal, 2013
Background: Few studies have addressed the indirect costs of chronic hepatitis B and C, and none has assessed the real costs of these conditions, including indirect costs caused by loss of work, in Turkey. Aims: This study therefore analysed the costs of
Fatma Banu Karahasanoğlu, Ali Asan, Suzan Sacar, Hüseyin Turgut   +3 more
doaj   +1 more source

Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey. [PDF]

PLoS ONE, 2018
AIM:Health-related quality of life is impaired in patients with autoimmune hepatitis, but the association between health-related quality of life and patients' backgrounds remains unknown.
Atsushi Takahashi, Kei Moriya, Hiromasa Ohira, Teruko Arinaga-Hino, Mikio Zeniya, Takuji Torimura, Masanori Abe, Akinobu Takaki, Jong-Hon Kang, Ayano Inui, Tomoo Fujisawa, Kaname Yoshizawa, Yoshiyuki Suzuki, Nobuhiro Nakamoto, Kazuhiko Koike, Hitoshi Yoshiji, Aya Goto, Atsushi Tanaka, Zobair M Younossi, Hajime Takikawa, Japan AIH Study Group   +20 more
doaj   +1 more source

Hepatitis C Virus Epidemic Control Using a Nonlinear Adaptive Strategy [PDF]

arXiv, 2020
Hepatitis C is a viral infection that appears as a result of the Hepatitis C Virus (HCV), and it has been recognized as the main reason for liver diseases. HCV incidence is growing as an important issue in the epidemiology of infectious diseases. In the present study, a mathematical model is employed for simulating the dynamics of HCV outbreak in a ...
arxiv  

Chronic hepatitis B: Update 2009

Hepatology, 2009
These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
A. Lok, B. McMahon
semanticscholar   +1 more source