Results 61 to 70 of about 3,185,529 (387)
Intracellular Dynamics of Hepatitis B Virus Infection: A Mathematical Model and Global Sensitivity Analysis of Its Parameters [PDF]
arXiv, 2023 Analysis of cell population can reveal the average information about the viral infection in host whereas single-cell analysis can capture the individual consideration. Single-cell analysis can also provide new ways to explore viral diversities and identify the intrinsic extreme phenotype of the cells. In this study, a single-cell hepatitis B virus (HBV)
arxiv
Hepatology, 2016 Chronic hepatitis B viral (HBV) infection remains a significant global health problem. Evidence‐based guidelines are needed to help providers determine when treatment should be initiated, which medication is most appropriate, and when treatment can ...
A. Lok +16 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang +9 more
wiley +1 more source
Evaluation of hepatocyte-derived microRNA-122 for diagnosis of acute and chronic hepatitis of dogs [PDF]
Veterinary World, 2018 Aim: This study was performed to evaluate the diagnostic value of hepatocyte-derived microRNA (miRNA)-122 in acute and chronic hepatitis of dogs.
S. R. Eman +5 more
doaj +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
A Non-Invasive Interpretable NAFLD Diagnostic Method Combining TCM Tongue Features [PDF]
arXiv, 2023 Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized by hepatic steatosis resulting from the exclusion of alcohol and other identifiable liver-damaging factors. It has emerged as a leading cause of chronic liver disease worldwide. Currently, the conventional methods for NAFLD detection are expensive and not suitable
arxiv
Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
Advanced Healthcare Materials, EarlyView.This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold +2 more
wiley +1 more source
A concise assessment of salivary modifications in patients with chronic hepatitis [PDF]
Romanian Journal of Medical Practice, 2017 Background. Saliva is a complex biological fluid that has great potential as a diagnosis fluid for both oral and systemic diseases. At the same time, chronic hepatitis affects millions of people worldwide and can lead to liver cirrhosis and ...
Daniela-Gabriela BADITA +7 more
doaj +1 more source
Journal of the American Medical Association (JAMA), 2012 CONTEXT Chronic hepatitis C virus (HCV) infection outcomes include liver failure, hepatocellular carcinoma (HCC), and liver-related death. OBJECTIVE To assess the association between sustained virological response (SVR) and all-cause mortality in ...
MD Adriaan J. van der Meer +14 more
semanticscholar +1 more source