Results 1 to 10 of about 1,075,752 (348)

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection.

New England Journal of Medicine, 2022
BACKGROUND Bepirovirsen is an antisense oligonucleotide that targets all hepatitis B virus (HBV) messenger RNAs and acts to decrease levels of viral proteins.
M. Yuen, S. Lim, R. Pleśniak, K. Tsuji, H. Janssen, Cristina Pojoga, A. Gadano, C. Popescu, T. Stepanova, T. Asselah, G. Diaconescu, H. Yim, J. Heo, E. Janczewska, Alexander Wong, N. Idriz, M. Imamura, G. Rizzardini, K. Takaguchi, P. Andreone, M. Arbune, J. Hou, Sung-Jae Park, A. Vâță, J. Cremer, R. Elston, T. Lukić, Geoff Quinn, L. Maynard, Stuart Kendrick, H. Plein, F. Campbell, M. Paff, D. Theodore   +33 more
semanticscholar   +1 more source

New Approaches to Chronic Hepatitis B.

New England Journal of Medicine, 2023
large HBV surface protein (LHBs) to the hepatocyte entry receptor ...
G. Dusheiko, K. Agarwal, M. Maini
semanticscholar   +1 more source

Current Trend in Antiviral Therapy for Chronic Hepatitis B

Viruses, 2022
Since active hepatitis B virus (HBV) replication is the key driver of hepatic necroinflammation and disease progression, the treatment aim of chronic hepatitis B (CHB) is to suppress HBV replication permanently to prevent hepatic decompensation, liver ...
R. Chien, Y. Liaw
semanticscholar   +1 more source

Improving Therapeutic Vaccination against Hepatitis B—Insights from Preclinical Models of Immune Therapy against Persistent Hepatitis B Virus Infection

Vaccines, 2021
Chronic hepatitis B affects more than 250 million individuals worldwide, putting them at risk of developing liver cirrhosis and liver cancer. While antiviral immune responses are key to eliminating hepatitis B virus (HBV) infections, insufficient ...
Percy A. Knolle, Li-Rung Huang, Anna Kosinska, Dirk Wohlleber, Ulrike Protzer   +4 more
doaj   +1 more source

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Hepatology, 2018
This AASLD 2018 Hepatitis B Guidance is intended to complement the AASLD 2016 Practice Guidelines for Treatment of Chronic Hepatitis B and update the previous hepatitis B virus (HBV) guidelines from 2009. The 2018 updated guidance on chronic hepatitis B (
N. Terrault, A. Lok, B. McMahon, Kyong‐Mi Chang, Jessica P. Hwang, M. Jonas, Robert S. Brown, N. Bzowej, J. Wong   +8 more
semanticscholar   +2 more sources

Effectiveness of hepatitis B hyperimmunglobulin and vaccine in preventing perinatal transmission in children born from a mother with chronic B hepatitis

Zdorovʹe Rebenka, 2021
Background. Viral hepatitis is still one of the important health problems all over the world today. Hepatitis B is a life-threatening liver infection that can cause chronic infections.
Feyza Gökben Kahveci, Hasret Ayyildiz Civan, Özgül Salihoğlu   +2 more
doaj   +1 more source

Different profiles of neurocognitive impairment in patients with hepatitis B and C virus infections

Scientific Reports, 2022
The direct impact of chronic hepatitis B and hepatitis C on neurocognition remains elusive due to the frequent comorbidities, and the domains of the neurocognitive functions affected have rarely been investigated comprehensively.
Chun-Hsiang Tan, Meng-Chia Chang, Wei-Fang Tsai, Wan-Long Chuang, Jee-Fu Huang, Zu-Yau Lin, Chia-Yen Dai, Ming-Lun Yeh, Chi-Ting Li, Rwei-Ling Yu   +9 more
doaj   +1 more source

A Study of the Relationship between Oxidative Stress and Risk of Developing Hepatocellular Carcinoma in People with Hepatitis B Infection; A Systematic Review Study

Asian Pacific Journal of Cancer Biology, 2022
Introduction: Hepatitis B infection is a severe global public health issue. It is the 10th biggest cause of death worldwide. Objective: This review focuses on the relationship between oxidative stress and the risk of developing of acute and chronic ...
Hammadi Nour, Chouia Maroua, Derouiche Samir   +2 more
doaj   +1 more source

Chronic hepatitis B exhibited higher rate of hepatocellular carcinoma occurrence than hepatitis C in cirrhotic patients after effective antiviral treatment

Journal of the Formosan Medical Association, 2021
Background/Purpose: Effective antiviral-therapy can reduce the risk of liver cirrhosis related hepatocellular carcinoma in patients with chronic hepatitis B and hepatitis C. Yet, the difference of hepatocellular carcinoma development in chronic hepatitis
Ming-Tsung Lin, Kuo-Chin Chang, Yi-Hao Yen, Ming-Chao Tsai, Chien-Hung Chen, Jing-Houng Wang, Chang-Chun Hsiao, Yueh-Hsia Chiu, Tsung-Hui Hu   +8 more
doaj   +1 more source

Prevalence of Chronic Hepatitis B Virus Infection in the United States.

American Journal of Gastroenterology, 2020
Chronic hepatitis B virus (HBV) infection represents a major global health problem, affecting an estimated 257-291 million persons worldwide and is associated with substantial morbidity and mortality because of clinical complications, such as liver ...
Joseph K. Lim, Mindie H. Nguyen, W. R. Kim, R. Gish, P. Perumalswami, Ira M. Jacobson   +5 more
semanticscholar   +1 more source