Results 31 to 40 of about 478,958 (264)

CLINICAL RELEVANCE OF PRECORE MUTATIONS OF HEPATITIS B VIRUS IN CHRONIC LIVER DISEASE [PDF]

, 2014
Introduction: Hepatitis B is one of the most frequent etiological factors for chronic liver diseases worldwide. Recent studies have suggested the important role of the genetic diversity of the virus on natural course of hepatitis B. Hepatitis B e-antigen
Chaloska Ivanova Viktorija, Curakova Elena, Genadieva Dimitrova Magdalena, Koloska Valentina, Todorovska Beti   +4 more
core   +2 more sources

Baseline quantitative HBcAb strongly predicts undetectable HBV DNA and RNA in chronic hepatitis B patients treated with entecavir for 10 years

Scientific Reports, 2021
The predictive effect of quantitative anti-hepatitis B core on double-negative HBV DNA and RNA remains unstudied. We observed dynamic changes in this measure in chronic hepatitis B patients receiving entecavir for 10 years, evaluating its predictive ...
Xi Zhang, Xiaocui An, Lei Shi, Xueliang Yang, Yunru Chen, Xiaojing Liu, Jianzhou Li, Feng Ye, Shumei Lin   +8 more
doaj   +1 more source

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

mBio
The persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA ...
Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Prevention of Hepatitis B Virus Transmission in Pregnancy [PDF]

, 2014
Chronic hepatitis B virus infection is a serious health problem in many countries, particularly in developing countries. In Asia-Pacific region, vertical transmission from mother to child is the main endemicity factor of hepatitis B virus (HBV) infection.
Praptiwi, D. R. (Dwi), Sanityoso, A. (Andri)   +1 more
core   +1 more source

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Emerging Microbes and Infections
Type I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection.
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Prevention of Hepatitis B Vertical Transmission: Focus on Antenatal Antiviral Administration

Jurnal Penyakit Dalam Indonesia, 2016
Hepatitis B is one of the main cause of chronic liver disease, and potentially cause cirrhosis, liver failure and hepatocellular carcinoma in 15-40% population. Globally, 2 billion people are infected by Hepatitis B.
Anandhara Indriani Khumaedi, About The Authors Anandhara Indriani Khumaedi Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo, Jakarta Indonesia Rino Alvani Gani, Irsan Hasan   +2 more
doaj   +1 more source

Liver transplantation for viral hepatitis in 2015 [PDF]

, 2016
Liver transplantation (LT) is a life-saving treatment for patients with end-stage liver disease and for patients with liver cell cancer related to liver disease.
Bortoluzzi, Ilaria, Burra, Patrizia, Ferrarese, Alberto, Gambato, Martina, Germani, Giacomo, Nadal, Elena, Russo, FRANCESCO PAOLO, Senzolo, Marco, Zanetto, Alberto   +8 more
core   +1 more source

Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure

Viruses
Chronic hepatitis B (CHB) remains a major global health challenge, largely due to the persistence of covalently closed circular DNA (cccDNA) and impaired host immunity.
Asha Ashuo, Jia Liu, Zhenghong Yuan, Jieliang Chen   +3 more
doaj   +1 more source

Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets [PDF]

, 2011
It has been shown that infection of GB virus B (GBV-B), which is closely related to HCV, develop acute self-resolving hepatitis in tamarins. In this study we sought to examine longitudinally the dynamics of viral and immunological status following GBV-B
Yuki Iwasaki, Ken-ichi Mori, Koji Ishii, Noboru Maki, Sayuki Iijima, Tomoyuki Yoshida, Sachi Okabayashi, Yuko Katakai, Young-Jung Lee, Akatsuki Saito, Hiromi Fukai, Nobuyuki Kimura, Naohide Ageyama, Sayaka Yoshizaki, Tetsuro Suzuki, Yasuhiro Yasutomi, Tatsuo Miyamura, Mari Kannagi, Hirofumi Akari   +18 more
core   +1 more source

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Virus Research
The detection of hepatitis B surface antigen (HBsAg) is fundamental for the diagnosis of chronic hepatitis B (CHB). However, current diagnostic assays that rely on antibodies targeting the conformational “a” determinant of HBsAg are frequently ...
Yansong Chen, Xinyu Zhang, Asha Ashuo, Zhong Fang, Wuhui Song, Jiangxia Liu, Jieliang Chen, Yaming Li, Zhenghong Yuan   +8 more
doaj   +1 more source