Results 51 to 60 of about 478,958 (264)

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Signal Transduction and Targeted Therapy
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explore combined RNA interference (RNAi) and ...
Wenjing Zai, Min Yang, Kuan Jiang, Juan Guan, Huijing Wang, Kongying Hu, Chao Huang, Jieliang Chen, Wei Fu, Changyou Zhan, Zhenghong Yuan   +10 more
doaj   +1 more source

The natural history of chronic hepatitis B infection [PDF]

, 1997
Chronic hepatitis B infection is a global health problem that affects about 300 million people. Of these, 75% are Chinese. Most Chinese who become chronic carriers, contract the virus during the perinatal period.
Lai, CL, Lau, GKK, Wu, PC
core  

Factors associated with spontaneous clearance of chronic hepatitis C virus infection [PDF]

, 2016
Background & Aims: Spontaneous clearance of chronic hepatitis C virus (HCV) infection (CHC) is rare. We conducted a retrospective case-control study to identify rates and factors associated with spontaneous clearance of CHC.
Aitken, Celia, Barclay , Stephen T, Bulteel, Naomi, Forrest, Ewan, Fox, Ray, Gunson, Rory, Innes, Hamish, Mills, Peter, Morris, Judith, Sarathy, Prasanna, Stanley, Adrian, Valerio, Heather   +11 more
core   +2 more sources

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

A Case Report of Hepatocellular Carcinoma 5 Years After HBsAg Loss in Chronic Hepatitis Delta: How Long Surveillance is Required?

Annals of Hepatology, 2017
Background: Hepatitis delta virus infection occurs as acute coinfection or as superinfection in patients with preexisting chronic hepatitis B. Chronic hepatitis delta leads to more severe disease than chronic hepatitis B, with more rapid progression of ...
Laura Escolà-Vergé, Mar Riveiro-Barciela, Maria Buti   +2 more
doaj   +1 more source

Future prevention and treatment of chronic hepatitis B infection [PDF]

, 2012
Vaccination for hepatitis B virus (HBV) infection and treatment for chronic hepatitis B, while effective for primary prevention and control of the disease, still have their limitations. Global coverage of HBV immunization needs improvement.
Fung, J, Lai, CL, Seto, WK, Yuen, MF
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Prevalence of Hepatitis B in Canadian First-Time Blood Donors: Association with Social Determinants of Health

Viruses
Hepatitis B is transmitted sexually, by blood contact, and vertically from mother to child. Chronic hepatitis B is often seen in immigrants from higher-prevalence countries and their Canadian-born children.
Sheila F. O’Brien, Behrouz Ehsani-Moghaddam, Mindy Goldman, Steven J. Drews   +3 more
doaj   +1 more source

Killer cell immunoglobulin-like receptor alleles influence susceptibility to occult hepatitis B infection in West African population

Journal of Public Health in Africa, 2023
Occult hepatitis B infection (OBI) is a public health problem in Burkina Faso. OBI represents a risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC).
Momeiyi M. Bazie, Florencia W. Djigma, Mahamoudou Sanou, Pegdwendé A. Sorgho, Abdoul K. Ouattara, Dorcas Obiri-Yeboah, Nadege Kapieko, Herman K. Sombie, Prosper Bado, Edwige T. Yelemkoure, Isabelle T. Kiendrebeogo, Marius B. Nagalo, Albert T. Yonli, Jacques Simpore   +13 more
doaj   +1 more source

Hepatitis B Screening and Vaccination Practices in Asian American Primary Care

Gut and Liver, 2013
Background/AimsScreening for hepatitis B virus (HBV) is recommended in populations with anticipated prevalence ≥2%. This study surveyed HBV screening and vaccination practices of Asian American primary care providers (PCPs).Methods : Approximately 15,000
doaj   +1 more source