Results 1 to 10 of about 85,177 (307)

Interferons - A Review

Journal of Indian Academy of Oral Medicine and Radiology, 2005
Interferons are a family of proteins and glycoproteins that have a variety of biologic actions. Interferons were first discovered in 1957 and several clinical trials have been conducted since then to unravel the action and clinical applications of ...
Karthikeya Patil, V G Mahima, Shwetha Shetty   +2 more
doaj   +1 more source

Effect of Acute Heat Stress on the mRNA Levels of Cytokines in Broiler Chickens Subjected to Embryonic Thermal Manipulation

Animals, 2019
Heat stress significantly impacts the immunity and cytokine expression of chickens. However, the effects of embryonic thermal manipulation (TM) on cytokine expression in broiler chickens (broilers) is unclear.
Khaled M. M. Saleh, Mohammad B. Al-Zghoul   +1 more
doaj   +1 more source

Combination Therapy for Chronic Hepatitis B: Current Updates and Perspectives

Gut and Liver, 2017
Nucleos(t)ide analogues (NUCs) and interferon have been used for several decades to treat chronic hepatitis B; however, the therapeutic response remains unsatisfactory.
Tung-Hung Su, Chun-Jen Liu
doaj   +1 more source

Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment

Frontiers in Immunology, 2021
In recent years, it became apparent that cancers either associated with viral infections or aberrantly expressing endogenous retroviral elements (EREs) are more immunogenic, exhibiting an intense intra-tumor immune cell infiltration characterized by a ...
Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Wallax Augusto Silva Ferreira, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina, Tiago da Silva Medina   +5 more
doaj   +1 more source

Poly I:C Pre-Treatment Induced the Anti-Viral Interferon Response in Airway Epithelial Cells

Viruses, 2023
Type I and III interferons are among the most important antiviral mediators. Increased susceptibility to infections has been described as being associated with impaired interferon response in asthmatic patients. In this work, we focused on the modulation
Hannah Mitländer, Zuqin Yang, Susanne Krammer, Janina C. Grund, Sabine Zirlik, Susetta Finotto   +5 more
doaj   +1 more source

Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI)

Cells, 2022
STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy caused by gain-of-function mutations in STING1 encoding stimulator of interferon genes (STING) protein.
Clémence David, Marie-Louise Frémond
doaj   +1 more source

Interferons in the treatment of myeloproliferative neoplasms

Therapeutic Advances in Hematology
Interferons are cytokines with immunomodulatory properties and disease-modifying effects that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years.
Pankit Vachhani, John Mascarenhas, Prithviraj Bose, Gabriela Hobbs, Abdulraheem Yacoub, Jeanne M. Palmer, Aaron T. Gerds, Lucia Masarova, Andrew T. Kuykendall, Raajit K. Rampal, Ruben Mesa, Srdan Verstovsek   +11 more
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Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez, Laura Cristina Gómez-Legorreta, Laura Alejandra López-Campa, Valeria Martínez-Torres, Marcos Alvarado-Silva, Araceli Posadas-Mondragón, Nallely Díaz-Lima, Hilda Arcelia Angulo-Mendez, Nancy R. Mejía-Domínguez, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Julio García-Cordero, Leticia Cedillo-Barrón, Sergio Roberto Aguilar-Ruíz, José Bustos-Arriaga   +14 more
doaj   +1 more source

Multiple sclerosis: evidence and controversies [PDF]

Revista Ciencias de la Salud, 2006
Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with
Ángela María Gutiérrez-Álvarez
doaj  

PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA

Детские инфекции (Москва), 2018
Objective: study of immune status indices in newborns  in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns  with non-specific clinical symptoms were studied.
L. V. Kravchenko
doaj   +1 more source