Results 11 to 20 of about 87,441 (309)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells. [PDF]
FEBS Open BioType I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Bonilla LE +10 more
europepmc +2 more sources
The use of intranasal interferon for prevention and treatment of acute respiratory infections
Aktualʹnaâ Infektologiâ, 2021 Interferons are cytokines that are produced by immunocompetent cells in response to the invasion of an infectious factor. The most important biological effect of interferons used in clinical practice is their ability to nonspecifically inhibit viral ...
S.О. Kramarov, V.V. Yevtushenko
doaj +1 more source
Interferons—Implications in the Immune Response to Respiratory Viruses
Microorganisms, 2023 Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that ...
Harrison C. Bergeron +2 more
doaj +1 more source
COVID-19 newer and emerging treatment options
Apollo Medicine, 2021 Coronavirus disease-19 is a highly contagious disease caused by severe acute respiratory syndrome coronavirus-2. It has shown a debilitating and catastrophic effect on the world population and is emerging as a challenging global health crisis, resulting ...
Suneetha Narreddy, Sneha Varahala
doaj +1 more source
Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
eLife, 2020 Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion.
Anusorn Mudla +9 more
doaj +1 more source
Interferons: Tug of War Between Bacteria and Their Host
Frontiers in Cellular and Infection Microbiology, 2021 Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs).
Noémie Alphonse +3 more
doaj +1 more source
Frontiers in Immunology, 2021 In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited.
Miriam Mojzesz +11 more
doaj +1 more source
Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]
, 2010 Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager +28 more
core +1 more source
The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway
Frontiers in Immunology, 2020 Interferons (IFNs) form a family of cytokines with pleiotropic effects that modulate the immune response against multiple challenges like viral infections, autoimmune diseases, and cancer. While numerous anti-tumor activities have been described for IFNs,
Laura Martin-Hijano +5 more
doaj +1 more source
Interferons in hematopoiesis and leukemia [PDF]
, 2013 Interferons not only exert a fundamental role during inflammation and immune responses but also modulate the activity of hematopoietic stem cells during homeostatic and demand-adapted hematopoiesis.
Ochsenbein, Adrian F. +5 more
core +2 more sources