Results 31 to 40 of about 80,233 (311)
mBio, 2022 As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion strategies, many of which are aimed at suppressing the production of type I interferons (IFNs).
Tate Tabtieng +4 more
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Clinical Evaluation of Interferons in Malignant Melanoma [PDF]
, 1990 The evaluation of interferons in the treatment of malignant melanoma has been mainly in the treatment of advanced disease using interferons as the sole agent or in combination with other agents.
McLeod, G.R., Hersey, P., Thomson, D.B.
core +1 more source
Interferons lambda – therapeutic application [PDF]
, 2020 Interferons are a group of protein molecules with a broad spectrum of effects on the human body. Interferon lambda (type III interferon) was discovered comparatively recently about 20 years ago and its action is still poorly understood.
N. A. Kikhtenko +4 more
core +2 more sources
Immuno, 2022 The pathogenesis of COVID-19 is complicated by immune dysfunction. The impact of immune-based therapy in COVID-19 patients has been well documented, with some notable studies on the use of anti-cytokine medicines.
Deepshikha Yadav +12 more
doaj +1 more source
Immunity, Inflammation and Disease, 2018 Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and ...
Sharon A. Oldford +6 more
doaj +1 more source
Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System
Viruses, 2021 Viral infections remain a global public health concern and cause a severe societal and economic burden. At the organismal level, the innate immune system is essential for the detection of viruses and constitutes the first line of defense.
Hina Singh, Jeffrey Koury, Marcus Kaul
doaj +1 more source
Evolution of Interferons and Interferon Receptors [PDF]
Frontiers in Immunology, 2017 The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei, holostei, and teleostei), as well as in tetrapods.
Secombes, Christopher John, Zou, Jun
openaire +3 more sources
HOW CELLS RESPOND TO INTERFERONS [PDF]
, 1998 Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct.
Bryan R. G. Williams +4 more
core +1 more source
Hepatitis C Virus Infection: Host–Virus Interaction and Mechanisms of Viral Persistence
Cells, 2019 Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune factors along with the actions of HCV proteins that promote viral ...
DeGaulle I. Chigbu +4 more
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African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
Viruses, 2023 African swine fever (ASF) is a hemorrhagic viral disease of domestic pigs and wild suids (all Sus scrofa) caused by the ASF virus (ASFV). The disease is spreading worldwide without control, threatening pig production due to the absence of licensed ...
Giulia Franzoni +2 more
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