Results 31 to 40 of about 87,441 (309)

An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

eLife, 2019
Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment.
Murilo Delgobo, Daniel AGB Mendes, Edgar Kozlova, Edroaldo Lummertz Rocha, Gabriela F Rodrigues-Luiz, Lucas Mascarin, Greicy Dias, Daniel O Patrício, Tim Dierckx, Maíra A Bicca, Gaëlle Bretton, Yonne Karoline Tenório de Menezes, Márick R Starick, Darcita Rovaris, Joanita Del Moral, Daniel S Mansur, Johan Van Weyenbergh, André Báfica   +17 more
doaj   +1 more source

Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection

Frontiers in Immunology, 2021
Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host ...
Krishna Latha, Katelyn F. Jamison, Wendy T. Watford   +2 more
doaj   +1 more source

Extreme heterogeneity of influenza virus infection in single cells

eLife, 2018
Viral infection can dramatically alter a cell’s transcriptome. However, these changes have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA sequencing to examine the transcriptional consequences of influenza virus ...
Alistair B Russell, Cole Trapnell, Jesse D Bloom   +2 more
doaj   +1 more source

IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages

Journal of Innate Immunity, 2022
Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead ...
Iris Aparici-Herraiz, Guillem Sánchez-Sánchez, Carlos Batlle, Pere Rehues, Martí López-Serrat, Lorena Valverde-Estrella, Jorge Lloberas, Antonio Celada   +7 more
doaj   +1 more source

Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection

mBio, 2022
As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion strategies, many of which are aimed at suppressing the production of type I interferons (IFNs).
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia   +4 more
doaj   +1 more source

Interferons in COVID-19: missed opportunities to prove efficacy in clinical phase III trials? [PDF]

, 2023
Interferons were repeatedly used in the therapy of COVID-19 due to their antiviral effects. Three recently published randomized controlled clinical phase III trials (WHO SOLIDARITY, ACTT-3, and SPRINTER) missed their primary objectives, i.e., a ...
Josef Brzoska, Manfred Hündgen, Harald von Eick   +2 more
core   +1 more source

Probing the Immune System Dynamics of the COVID-19 Disease for Vaccine Designing and Drug Repurposing Using Bioinformatics Tools

Immuno, 2022
The pathogenesis of COVID-19 is complicated by immune dysfunction. The impact of immune-based therapy in COVID-19 patients has been well documented, with some notable studies on the use of anti-cytokine medicines.
Deepshikha Yadav, Shriya Agarwal, Pranav Pancham, Divya Jindal, Vinayak Agarwal, Premshankar Kumar Dubey, Saurabh K. Jha, Shalini Mani, Rachana, Abhijit Dey, Niraj Kumar Jha, Kavindra Kumar Kesari, Manisha Singh   +12 more
doaj   +1 more source

Interferon α2 and interferon γ induce the degranulation independent production of VEGF‐A and IL‐1 receptor antagonist and other mediators from human mast cells

Immunity, Inflammation and Disease, 2018
Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and ...
Sharon A. Oldford, Suzanne P. Salsman, Liliana Portales‐Cervantes, Raidan Alyazidi, Robert Anderson, Ian D Haidl, Jean S. Marshall   +6 more
doaj   +1 more source

Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System

Viruses, 2021
Viral infections remain a global public health concern and cause a severe societal and economic burden. At the organismal level, the innate immune system is essential for the detection of viruses and constitutes the first line of defense.
Hina Singh, Jeffrey Koury, Marcus Kaul
doaj   +1 more source

Hepatitis C Virus Infection: Host–Virus Interaction and Mechanisms of Viral Persistence

Cells, 2019
Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune factors along with the actions of HCV proteins that promote viral ...
DeGaulle I. Chigbu, Ronak Loonawat, Mohit Sehgal, Dip Patel, Pooja Jain   +4 more
doaj   +1 more source