Results 51 to 60 of about 80,233 (311)

Interferons and their potential in the treatment of ocular inflammation [PDF]

, 2009
Friederike Mackensen,1 Regina Max,2 Matthias D Becker31Department of Ophthalmology, 2Department of Internal Medicine, Interdisciplinary Uveitis Center, University of Heidelberg, Germany; 3Department of Ophthalmology, Triemli Hospital Zürich ...
Regina Max, Matthias D Becker, Friederike Mackensen   +2 more
core  

Interferons and Collagen Production [PDF]

, 1990
The immunoregulatory, antiviral, and antiproliferative agents known as the interferons have profound effects on collagen synthesis. Interferons α, β and γ suppress collagen synthesis by dermal fibroblasts.
Amento, Edward P., Granstein, Richard D., Flotte, Thomas J.   +2 more
core   +1 more source

Combination Therapy for Chronic Hepatitis B: Current Updates and Perspectives

Gut and Liver, 2017
Nucleos(t)ide analogues (NUCs) and interferon have been used for several decades to treat chronic hepatitis B; however, the therapeutic response remains unsatisfactory.
Tung-Hung Su, Chun-Jen Liu
doaj   +1 more source

Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment

Frontiers in Immunology, 2021
In recent years, it became apparent that cancers either associated with viral infections or aberrantly expressing endogenous retroviral elements (EREs) are more immunogenic, exhibiting an intense intra-tumor immune cell infiltration characterized by a ...
Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Wallax Augusto Silva Ferreira, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina, Tiago da Silva Medina   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

INTERFERONS AND EYE DISEASES [PDF]

, 2019
The review contains an analysis of the medical use of interferons – a group of signaling protein molecules that have antiviral, antitumor, and immunomodulatory activity – in ophthalmic practice.
N. A. Kikhtenko, P. G. Madonov
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Type 1 interferons as a potential treatment against COVID-19 [PDF]

, 2020
Elsevier Public Health emergency CollectionInternational audienceType 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV.
Sallard, Erwan, Lescure, François-Xavier, Mentré, France, Yazdanpanah, Yazdan, Peiffer-Smadja, Nathan   +4 more
core   +1 more source

Poly I:C Pre-Treatment Induced the Anti-Viral Interferon Response in Airway Epithelial Cells

Viruses, 2023
Type I and III interferons are among the most important antiviral mediators. Increased susceptibility to infections has been described as being associated with impaired interferon response in asthmatic patients. In this work, we focused on the modulation
Hannah Mitländer, Zuqin Yang, Susanne Krammer, Janina C. Grund, Sabine Zirlik, Susetta Finotto   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source