Results 71 to 80 of about 80,233 (311)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Regulation of Class I Genes by Interferons [PDF]
, 1988 Major histocompatibility (MHC) class I gene expression is increased in response to interferons. In order to identify critical regulatory regions in mouse MHC (H-2) class I genes, the 5' flanking region and the DNA downstream of the transcription ...
Korber, Bette Tina Marie
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Multiple sclerosis: evidence and controversies [PDF]
Revista Ciencias de la Salud, 2006 Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with
Ángela María Gutiérrez-Álvarez
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Детские инфекции (Москва), 2018 Objective: study of immune status indices in newborns in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns with non-specific clinical symptoms were studied.
L. V. Kravchenko
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Interferons as Therapeutic Agents in Infectious Diseases [PDF]
, 2011 This article explains the rationale for development of interferons as therapeutic agents, and describes commercial products available today. It also provides a summary of studies that have been performed with interferons for use as exogenous biological ...
Santanello, Cathy +2 more
core +1 more source
Mouse Interferons: Amino Terminal Amino Acid Sequences of Various Species [PDF]
, 1980 Mouse interferons of three size classes (A, 35,000 to 40,000 daltons; B, 26,000 to 33,000 daltons; and C, 20,000 daltons) were purified from Ehrlich ascites tumor cells infected with Newcastle disease virus.
Hideharu Taira +17 more
core +1 more source
Brain-Derived Neurotrophic Factor in Multiple Sclerosis Disability: A Prospective Study
Brain SciencesMultiple sclerosis (MS) is a demyelinating central nervous system disease that leads to neurological disability. Brain-derived neurotrophic factors (BDNFs) are neurotrophins involved in neurodegenerative disorders.
Vitalie Vacaras +9 more
doaj +1 more source
Pharmaceutical and Biomedical Research, 2021 Background: There is an intense search for the Coronavirus Disease 19 (COVID-19) cure, to stem the spread and burden of the disease worldwide. Studies revealed that epigenetic modifications impact the pathogenesis of some COVID-19 cases, which can be ...
Tajudeen Yahaya +4 more
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