Results 61 to 70 of about 80,233 (311)

Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon [PDF]

, 2002
Production of alpha/beta interferons (IFN-α/β) in response to viral infection is one of the main defense mechanisms of the innate immune system. Many viruses therefore encode factors that subvert the IFN system to enhance their virulence.
Richard E. Randall, Randall, Richard E, Friedemann Weber, Fazakerley, John K., Nina Kessler, Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, Elliott, Richard M, Randall, R.E., Kessler, N, Elliott, R.M., Streitenfeld, H., Richard M. Elliott, Kessler, N., Anne Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J.K., Kessler, Nina, Hein Streitenfeld, Bridgen, A, Elliott, Richard Michael, Fazakerley, JK, John K. Fazakerley, Bridgen, Anne, Randall, Richard Edward   +29 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interferons [PDF]

, 1992
LR: 20061107; PUBM: Print; JID: 7501160; 9008-11-1 (Interferons); 9035-51-2 (Cytochrome P-450 Enzyme System); CON: JAMA. 1991 Sep 11;266(10):1375-83.

core  

The New Alpha Interferons [PDF]

, 1985
Alpha interferons are biological response modifiers that regulate immune function, slow cell proliferation, and inhibit virus replication. Large supplies of purified preparations are now available for clinical trials.
Donald C. McLeod, Carol McManus Balmer
core   +1 more source

Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI)

Cells, 2022
STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy caused by gain-of-function mutations in STING1 encoding stimulator of interferon genes (STING) protein.
Clémence David, Marie-Louise Frémond
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Structural model for interferons [PDF]

, 1985
Secondary structures of leucocyte α1- and α2-interferons and of fibroblast β-interferon are calculated using the molecular theory of protein secondary structures.
Ptitsyn, O.B., A.V. Finkelstein, A.G. Murzin, Murzin, A.G., O.B. Ptitsyn, Finkelstein, A.V.   +5 more
core   +1 more source

Interferons in Viral Infections [PDF]

Interferons (IFNs) are cytokines that inhibit viral replication in host cells by triggering innate immune responses through the transcriptional induction of various IFN-stimulated genes (ISGs) [...
Pracheta Sengupta, Chattopadhyay, Saurabh, Sengupta, Pracheta, Saurabh Chattopadhyay   +3 more
core   +2 more sources

Interferons in the treatment of myeloproliferative neoplasms

Therapeutic Advances in Hematology
Interferons are cytokines with immunomodulatory properties and disease-modifying effects that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years.
Pankit Vachhani, John Mascarenhas, Prithviraj Bose, Gabriela Hobbs, Abdulraheem Yacoub, Jeanne M. Palmer, Aaron T. Gerds, Lucia Masarova, Andrew T. Kuykendall, Raajit K. Rampal, Ruben Mesa, Srdan Verstovsek   +11 more
doaj   +1 more source

Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez, Laura Cristina Gómez-Legorreta, Laura Alejandra López-Campa, Valeria Martínez-Torres, Marcos Alvarado-Silva, Araceli Posadas-Mondragón, Nallely Díaz-Lima, Hilda Arcelia Angulo-Mendez, Nancy R. Mejía-Domínguez, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Julio García-Cordero, Leticia Cedillo-Barrón, Sergio Roberto Aguilar-Ruíz, José Bustos-Arriaga   +14 more
doaj   +1 more source