Results 21 to 30 of about 80,233 (311)
Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy
Cells, 2023 Innate immune signaling in adipocytes affects systemic metabolism. Cytosolic nucleic acid sensing has been recently shown to stimulate thermogenic adipocyte differentiation and protect from obesity; however, DNA efflux from adipocyte mitochondria is a ...
Kornél Z. Varga +8 more
doaj +1 more source
Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression [PDF]
, 2005 Type 1 interferons (IFN-?/?) are key mediators of innate antiviral responses but havelittle effect on established replication of dengue viruses, which are mosquito-borneflaviviruses of immense global health importance.
Jones, M +9 more
core +1 more source
Salmonella Typhimurium infection: Type I Interferons integrate cellular networks to disintegrate macrophages [PDF]
, 2018 Type I interferons have immunomodulatory functions during infection with bacteria and viruses. They are vital for the host defense against viruses and extracellular bacteria. However, recent evidences show that IFN-I contributes to immunopathology during
Robinson, N., Nirmal Robinson
core +1 more source
eLife, 2019 Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment.
Murilo Delgobo +17 more
doaj +1 more source
Frontiers in Immunology, 2021 Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host ...
Krishna Latha +2 more
doaj +1 more source
Interferons in the treatment of human cancer. [PDF]
, 1984 The interferons are the best known of biologic antineoplastic agents. Progress with the clinical application of interferons to cancer has been slow and complicated by the need for attention to a new spectrum of therapeutic and toxic effects manifest by ...
J M Kirkwood, M S Ernstoff
core +1 more source
Type I Interferons in the Pathogenesis and Treatment of Sjögren’s Syndrome: An Update [PDF]
, 2022 Type I interferons (IFN) are widely expressed cytokines that play a pivotal role in the cell-intrinsic antimicrobial process, especially in viral infections.
Weiqian Chen, Yiduo Sun, Jin Lin
core +1 more source
Extreme heterogeneity of influenza virus infection in single cells
eLife, 2018 Viral infection can dramatically alter a cell’s transcriptome. However, these changes have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA sequencing to examine the transcriptional consequences of influenza virus ...
Alistair B Russell +2 more
doaj +1 more source
Molecular characterization and antiviral analyses of porcine type III interferons [PDF]
, 2010 Type III interferons (IFNs) are a family of recently identified antiviral cytokines. One to 3 paralogs have been identified in several species; however, little information is available about type III IFNs in pigs.
Rowland, Raymond R. R. +5 more
core +2 more sources
IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages
Journal of Innate Immunity, 2022 Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead ...
Iris Aparici-Herraiz +7 more
doaj +1 more source