Results 111 to 120 of about 1,109,482 (395)

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV [PDF]

, 2016
IFN-α has been used for decades to treat chronic hepatitis B and C, and as an off-label treatment for
Brandsma, J.H. (Johan), Fuhler, G.M. (Gwenny), Hakim, M.S. (Mohamad), Laan, L.J.W. (Luc) van der, Metselaar, H.J. (Herold), Pan, Q. (Qiuwei), Peppelenbosch, M.P. (Maikel), Poot, R.A. (Raymond), Smits, M.J.M. (Ron), Sprengers, D. (Dave), Wang, W. (Wenshi), Wang, Y. (Yijin), Woude, C.J. (Janneke) van der, Xu, L. (Lei), Yin, Y. (Yuebang), Zhou, X. (Xinying)   +15 more
core   +2 more sources

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Hepatitis B and Hepatitis C Co-infection: Treatment Approaches and A Case Report

Viral Hepatitis Journal
Hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection is a significant health issue worldwide and can accelerate liver damage when they occur together.
Mirkan Bulğak, Tuna Demirdal
doaj   +1 more source

Chronic hepatitis C genotype 6 responds better to pegylated interferon and ribavirin combination therapy than genotype 1 [PDF]

, 2009
Owen T‐Y Tsang, J. Zee, Jacky M‐C Chan, Reggie S‐T Li, Yee‐Man Kan, F.T.W. Li, F H Lo, DAVID ALAN CHOW, Kent W‐L Cheung, Kam‐Hon Chan, Yat‐Wah Yeung, Fook–Hong Ng, Michael K. K. Li, W K Kwan, Thomas S‐T Lai   +14 more
openalex   +1 more source

Bicyclol for chronic hepatitis C

Cochrane Database of Systematic Reviews, 2007
Bicyclol is a novel synthetic 'anti-hepatitis' drug, used in China for chronic hepatitis C. Until now, systematic reviews on bicyclol therapy have not been performed.To study the benefits and harms of bicyclol for patients with chronic hepatitis C.We searched The Cochrane Hepato-Biliary Group Controlled Trials Register (July 2005), the Cochrane Central
Yang, Xiaoyan, Zhuo, Qi, Wu, Taixiang, Liu, Guan Jian   +3 more
openaire   +2 more sources

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА ХРОНИЧЕСКИХ ГЕПАТИТОВ И ЦИРРОЗОВ ПЕЧЕНИ РАЗЛИЧНОЙ ЭТИОЛОГИИ

Архивъ внутренней медицины, 2015
The review of literature discusses the clinical and biochemical changes in patients with chronic hepatitis C, chronic hepatitis of alcoholic etiology, chronic hepatitis combined genesis (HCV + alcohol) and cirrhosis in the outcome of hepatitis, liver ...
А. Р. Билалова, В. В. Макашова   +1 more
doaj   +1 more source

Applicability of Hepatitis C Virus RNA Viral Load Thresholds for 8-Week Treatments in Patients With Chronic Hepatitis C Virus Genotype 1 Infection [PDF]

, 2016
Johannes Vermehren, Benjamin Maasoumy, Raoel Maan, Gavin Cloherty, C. Berkowski, Jordan J. Feld, Markus Cornberg, Jean–Michel Pawlotsky, Stefan Zeuzem, Michael P. Manns, Christoph Sarrazin, Heiner Wedemeyer   +11 more
openalex   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Acute hepatitis C virus (HCV) infection in chronic carriers of hepatitis B virus (HBV): the impact of underlying active HBV replication on persistence of HCV infection and antibody responses to HCV [PDF]

, 2002
Chung‐Ming Chu, Chau‐Ting Yeh, I‐Shyan Sheen, Yun‐Fan Liaw   +3 more
openalex   +1 more source