Results 81 to 90 of about 1,924,182 (309)

Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study [PDF]

, 2016
Background: Chronic infection by Trypanosoma cruzi could cause heart conduction disturbances. We sought to analyze electrocardiographic abnormalities among children with chronic T. cruzi infection with and without trypanocidal treatment with benznidazole.
Colantonio, Lisandro Damián, Prado, Nilda, Segura, Elsa Leonor, Sosa-Estani, Sergio Alejandro   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PD-1 signaling promotes control of chronic viral infection by restricting type-I-interferon-mediated tissue damage [PDF]

, 2019
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to disease or death. However, it is unclear how the host immune system balances control of infection and protection from the collateral tissue damage.
Egawa, Takeshi, Raju, Saravanan, Verbaro, Daniel J   +2 more
core   +1 more source

An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis [PDF]

, 2015
BACKGROUND: Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies.
Bell, SC, Currie, BJ, Geake, JB, Reid, DW   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy [PDF]

, 2006
BACKGROUND: The epidemiology of acute hepatitis C has changed during the past decade in Western countries. Acute HCV infection has a high rate of chronicity, but it is unclear when patients with acute infection should be treated.
Ancarani, Fausto, Antonucci, Giorgio, Babudieri, Sergio, Cariti, Giuseppe, Di Marco, Vito, Fabris, Paolo, Ferrari, Carlo, Francavilla, Ruggero, Massari, Marco, Medda, Emanuela, Pastore, Giuseppe, Santantonio, Teresa, Scotto, Gaetano, Stroffolini, Tommaso, Toti, Mario   +14 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CHRONIC ORAL INFECTIONS [PDF]

Archives of Internal Medicine, 1912
In 1891 Miller, in the preface to a series of articles 1 entitled "The Human Mouth as a Focus of Infection," says: During the last few years the conviction has grown continually stronger among physicians, as well as dentists, that the human mouth as a gathering-place and incubator of pathogenic germs performs a significant role in the production of ...
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multinucleated Giant Cell Formation as a Portal to Chronic Bacterial Infections

Microorganisms, 2020
This review provides a snapshot of chronic bacterial infections through the lens of Burkholderia pseudomallei and detailing its ability to establish multi-nucleated giant cells (MNGC) within the host, potentially leading to the formation of ...
Jacob L. Stockton, Alfredo G. Torres
doaj   +1 more source