Results 71 to 80 of about 1,336,163 (318)

A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers

, 2012
Background and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV ...
Stefan Zeuzem, Jörn Lötsch, Doehring, Alexandra, Vermehren, Johannes, Alexandra Doehring, Susser, Simone, Annemarie Berger, Sarrazin, Christoph, Sabine Wicker, Berger, Annemarie, Lötsch, Jörn, Christoph Sarrazin, Johannes Vermehren, Wicker, Sabine, Simone Susser, Zeuzem, Stefan   +15 more
core   +1 more source

Phosphorylation of Toxoplasma gondii Secreted Proteins during Acute and Chronic Stages of Infection

mSphere, 2020
The intracellular parasite Toxoplasma gondii resides within a membrane-bound parasitophorous vacuole (PV) and secretes an array of proteins to establish this replicative niche.
Joanna C. Young, Malgorzata Broncel, Helena Teague, Matt R. G. Russell, Olivia L. McGovern, Matt Renshaw, David Frith, Ambrosius P. Snijders, Lucy Collinson, Vern B. Carruthers, Sarah E. Ewald, Moritz Treeck   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity

, 2012
Aim: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined.
Kronenberger Bernd, Stefan Zeuzem, Reichert, David, Kronenberger, Bernd, Martinez, Yolanda, Martinez Yolanda, Bernd Kronenberger, Susser, Simone, Sarrazin, Christoph, Herrmann Eva, Susser Simone, Zeuzem Stefan, Piiper, Albrecht, Christoph Sarrazin, Simone Susser, Reichert David, Piiper Albrecht, Herrmann, Eva, Sarrazin Christoph, Martin-Walter Welker, Welker Martin-Walter, Albrecht Piiper, Eva Herrmann, Welker, Martin-Walter, David Reichert, Zeuzem, Stefan, Yolanda Martinez   +26 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection

, 2011
Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Nashwa Abousamra, Azza Azza Abdel-Aziz, Mona Elhadidy, Mohamed Abd-elmaksoud, Yahia Gad, Nasser Mousa   +5 more
core  

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +1 more source

CD4CD25 Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection [PDF]

, 2011
Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity.
Adrian P. Mountford, Aynsley, Sarah A, Sarah A. Aynsley, Cook, Peter C, Hogg, Karen G., Karen G. Hogg, Peter C. Cook, Mark C. Coles, Cook, Peter C; id_orcid, Peter C Cook, Cook Peter C., Cook, Peter C., Aynsley, Sarah A., Mountford Adrian P., Joseph D. Turner, Gavin R Jenkins, Aynsley Sarah A., Mountford, Adrian P, Paveley, Ross A., Ross A Paveley, Ross A. Paveley, Coles, Mark C, Turner, Joseph, Karen G Hogg, Hogg Karen G., Jenkins, Gavin R., Adrian P Mountford, Turner, Joseph D, Sarah A Aynsley, Paveley Ross A., Coles Mark C., Gavin R. Jenkins, Paveley, Ross A, Jenkins, Gavin R, Mark C Coles, Coles, Mark C., Hogg, Karen G, Joseph D Turner, Jenkins Gavin R., Mountford, Adrian P., Turner Joseph D.   +40 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The role of airway infection in chronic obstructive pulmonary disease

, 2006
PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core