Results 51 to 60 of about 1,292,965 (269)

Immune Checkpoints in Viral Infections

Viruses, 2020
As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system ...
Huiming Cai, Ge Liu, Jianfeng Zhong, Kai Zheng, Haitao Xiao, Chenyang Li, Xun Song, Ying Li, Chenshu Xu, Haiqiang Wu, Zhendan He, Qinchang Zhu   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A Biologically Optimized PEG-IFN-α2 Variant Exhibits Potent Anti-HBV and Immunomodulatory Efficacy

Emerging Microbes and Infections
Human interferon-alpha (IFN-α) includes 13 subtypes, but only IFN-α2 (a/b) is clinically approved for chronic hepatitis B (CHB) therapy, limited by adverse effects and suboptimal response rates.
Asha Ashuo, Jianyu Ye, Ruohan Jia, Yumeng Li, Yansong Chen, Zhong Fang, Michael Zhiyan Wang, Jieliang Chen, Zhenghong Yuan   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure

Viruses
Chronic hepatitis B (CHB) remains a major global health challenge, largely due to the persistence of covalently closed circular DNA (cccDNA) and impaired host immunity.
Asha Ashuo, Jia Liu, Zhenghong Yuan, Jieliang Chen   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Virus Research
The detection of hepatitis B surface antigen (HBsAg) is fundamental for the diagnosis of chronic hepatitis B (CHB). However, current diagnostic assays that rely on antibodies targeting the conformational “a” determinant of HBsAg are frequently ...
Yansong Chen, Xinyu Zhang, Asha Ashuo, Zhong Fang, Wuhui Song, Jiangxia Liu, Jieliang Chen, Yaming Li, Zhenghong Yuan   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Exploring the role of multi-pathogen infections in Alzheimer’s disease: A case–control study

Virulence
Background Alzheimer’s disease (AD) is a leading cause of dementia. Following the discovery of the amyloid’s antimicrobial properties, research has focused on infectious agents as potential contributors. This study investigates the role of multi-pathogen
Victor Garcia-Bustos, Marta Dafne Cabanero-Navalon, Carmen Lloret-Sos, MariaDolores Gómez, Miguel Baquero, Santos Ibanez-Barcelo, Javier Grimaldos, Consuelo Cháfer-Pericás   +7 more
doaj   +1 more source