Results 81 to 90 of about 1,273,492 (269)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Higher diagnostic value of metagenomic next-generation sequencing in acute infection than chronic infection: a multicenter retrospective study

Frontiers in Microbiology
BackgroundThe aim of this study is to compare the diagnostic value of metagenomic next-generation sequencing (mNGS) vs. conventional culture methods (CM) in chronic infection and acute infection.MethodsWe retrospectively analyzed the bronchoalveolar ...
Anjie Yao, Jiale Wang, Qintao Xu, Qintao Xu, Qintao Xu, Binay Kumar Shah, Kai Sun, Feng Hu, Changhui Wang, Shuanshuan Xie   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Human Norovirus Evolution in a Chronically Infected Host

mSphere, 2017
Typically, human noroviruses cause symptoms of acute gastroenteritis for 2 to 4 days. Often, the virions are shed in stool for several days after the symptoms recede, which in turn can lead to further contamination and transmission. Moreover, a number of
Sylvie Y. Doerflinger, Stefan Weichert, Anna Koromyslova, Martin Chan, Christian Schwerk, Ruediger Adam, Stefan Jennewein, Grant S. Hansman, Horst Schroten   +8 more
doaj   +1 more source

The Tonsil as a Chronic Infective Focus [PDF]

Southern Medical Journal, 1915
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openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mitochondria: A Covert Chronic Infection Masquerading as a Symbiotic Partner?

Frontiers in Bioscience-Landmark
Mitochondria, ubiquitous in eukaryotic cells, evolved from an ancestral aerobic alpha-proteobacterium that had been phagocytosed by a primordial archaeal cell.
George B. Stefano
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Brain endothelial PTPRO drives LPS-induced metabolic reprogramming and neuroinflammation in sepsis-associated encephalopathy

Journal of Neuroinflammation
Background Sepsis-associated encephalopathy (SAE) is characterized by profound neuroinflammation and blood–brain barrier (BBB) disruption, yet the molecular mechanisms linking endothelial metabolic reprogramming to neuroinflammatory responses remain ...
Fengjiao Wu, Haitao Tang, Haoxuan Jia, Chang Li, Yuwei Song, Jiwei Hu, He Cao, Benben Zhang, Xiaoyu Zhang, Hairui Jiang, Zhengyan Pan, Wusheng Zhou, Zongming Gou, Tianzhen Li, Tianbao Li, Hongtao Wang, Huaxue Wang, Zhongqing Qian, Ting Wang   +18 more
doaj   +1 more source