Results 91 to 100 of about 3,472,002 (291)

Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease [PDF]

Objectives: Chronic obstructive pulmonary disease (COPD) is one of the main late complications of sulfur mustard poisoning. The aim of this study was to evaluate serum levels of interleukin (IL)-6 in war veterans with pulmonary complications of sulfur ...
خواجه دلوئی, محمد, Shahrzad Lari, توحیدی, محمد, آیت اللهی, حسین, محمدزاده لاری, شهرزاد, قبادی مراللو, حسن, عطاران, داود, بصیری, رضا, قانعی, مصطفی   +8 more
core   +1 more source

Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease [PDF]

, 2014
Claire Brockwell,1 Sundari Ampikaipakan,1,2 Darren W Sexton,1 David Price,3,4 Daryl Freeman,5 Mike Thomas,6 Muzammil Ali,4 Andrew M Wilson1,21Norwich Medical School, University of East Anglia, Norwich, UK; 2Norfolk and Norwich University Hospital ...
Freeman, D, Wilson, AM, Thomas, Mike, Brockwell, Claire, Ampikaipakan, Sundari, Thomas M, Ampikaipakan, S, Ali, M, Sexton, Darren W., Freeman, Daryl, Brockwell C, Ampikaipakan S, Thomas, M., Wilson, Andrew M., Brockwell, C, Freeman D, Ali M, Sexton, DW, Sexton DW, Price, D, Price, David, Ali, Muzammil, Thomas, M, Price D, Wilson AM   +24 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review

Journal of Ovarian Research
Extracellular vesicles (EVs), particles enriched in bioactive molecules like proteins, nucleic acids, and lipids, are crucial mediators of intercellular communication and play key roles in various physiological and pathological processes.
Cyntia Duval, Brandon A. Wyse, Benjamin K. Tsang, Clifford L. Librach   +3 more
doaj   +1 more source

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation [PDF]

, 2010
The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function ...
Steven T. Proulx, Stefan Ullmann, Kari Alitalo, Alitalo, Kari, Detmar, Michael, Bronislaw Pytowski, Proulx, Steven T., Ullmann, Stefan, Reto Huggenberger, Pytowski, Bronislaw, Proulx, Steven T, Huggenberger, Reto, Michael Detmar   +12 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pathogen burden, inflammation, proliferation and apoptosis in human in-stent restenosis - Tissue characteristics compared to primary atherosclerosis [PDF]

, 2004
Pathogenic events leading to in-stent restenosis (ISR) are still incompletely understood. Among others, inflammation, immune reactions, deregulated cell death and growth have been suggested. Therefore, atherectomy probes from 21 patients with symptomatic
Wernert, N., Luderitz, B., Dinkelbach, S., Skowasch, D., Bauriedel, G., Schiele, T. M., Jabs, A., Andrie, R.   +7 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A semi-automated imaging and analysis pipeline for NET quantification and temporal-profiling of NETosis

Frontiers in Immunology
NETosis is a distinct form of neutrophil cell death involved in innate immunity and characterized by the release of DNA, that when dysregulated contributes to tissue damage and target-organ injury.
Chloé Landry, Chloé Landry, Liyuan Wang, Emma Gerber, Emma Gerber, Chet Elliot Holterman, Chet Elliot Holterman, Dylan Burger, Dylan Burger   +8 more
doaj   +1 more source

Exploring Impact of Rare Variation in Systemic Lupus Erythematosus by a Genome Wide Imputation Approach

Frontiers in Immunology, 2019
The importance of low frequency and rare variation in complex disease genetics is difficult to estimate in patient populations. Genome-wide association studies are therefore, underpowered to detect rare variation.
Manuel Martínez-Bueno, Marta E. Alarcón-Riquelme   +1 more
doaj   +1 more source