Results 111 to 120 of about 3,472,002 (291)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Frontiers in Immunology
BackgroundFactors leading to severe COVID-19 remain partially known. New biomarkers predicting COVID-19 severity that are also causally involved in disease pathogenesis could improve patient management and contribute to the development of innovative ...
Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)   +30 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification of mitochondria-related biomarkers in liver fibrosis via interpretable machine learning and WGCNA: transcriptomic analysis and In Vivo validation

Frontiers in Immunology
BackgroundHepatic fibrosis is a key pathological stage in the progression of many chronic liver diseases; timely intervention is critical to preventing cirrhosis and hepatocellular carcinoma.
Yupeng Ma, Yupeng Ma, Xinhong Chen, Lujin Yin, Yongbin Chi, Denghai Zhang, Xiaocheng Xue, Xue Zhang   +7 more
doaj   +1 more source

Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation

, 2008
Objective: We have applied here a model of chronic granulomatous inflammation to study the profile of mast cell activation and their expression of annexin-A1 in the nodular lesion.Materials: Granulomatous inflammation was induced by injection of croton ...
Ciocca, G. A. Panin [UNESP], Oliani, S. M. [UNIFESP], Damazo, A. S., Pimentel, T. A., Oliani, S. M. [UNESP], Damazo, Amilcar Sabino [UNIFESP], Gibbs, L., Oliani, S. M., Damazo, A. S. [UNESP], Perretti, M., Ciocca, G. A. Panin, Pimentel, T. A. [UNIFESP]   +11 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The role of adipokines in chronic inflammation

, 2016
Peter Mancuso Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA Abstract: Adipose tissue has traditionally been defined as connective tissue that stores excess calories in the form of triacylglycerol.
Mancuso P
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Circulating plasma gelsolin and MRI-based radiomics as biomarkers of platinum resistance in epithelial ovarian cancer: building a multiparameteric prediction algorithm

Journal of Ovarian Research
Background Resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) patients is a barrier to disease management. Currently, there are no biomarkers to predict chemoresistance.
Emma Gerber, Rahul Singh, Cheuk Nam Hwang, Lei Cai, Alice S. T. Wong, Dylan Burger, Karen K. L. Chan, Benjamin K. Tsang, Elaine Y. P. Lee   +8 more
doaj   +1 more source

The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

, 2013
Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that analogues of the glucagon-like polypeptide 1 (GLP-1) such as liraglutide have potent ...
Parthsarathy, Vadivel, Hölscher, Christian   +1 more
core   +1 more source