Results 51 to 60 of about 3,472,002 (291)

Chronic immune activation and inflammation as the cause of malignancy [PDF]

, 2001
Several chronic infections known to be associated with malignancy have established oncogenic properties. However the existence of chronic inflammatory conditions that do not have an established infective cause and are associated with the development of ...
Dalgleish, AG, O'Byrne, KJ, O'Byrne, Kenneth J., Dalgleish, A. G., K J O'Byrne, A G Dalgleish   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Macrophage-targeted therapy of chronic wounds

, 2022
S.195-216The formation of chronic wounds is associated with dysregulated inflammation - a multicausal pathophysiological event - resulting in difficult and inefficient treatment.
Huhn, M., Hristodorov, D., Thepen, T., Aslanian, E., Mladenov, R., Barth, S.   +5 more
core   +1 more source

Enteric Tuft Cells in Host-Parasite Interactions

Pathogens, 2021
Enteric tuft cells are chemosensory epithelial cells gaining attention in the field of host-parasite interactions. Expressing a repertoire of chemosensing receptors and mediators, these cells have the potential to detect lumen-dwelling helminth and ...
Sruthi Rajeev, Olivia Sosnowski, Shuhua Li, Thibault Allain, André G. Buret, Derek M. McKay   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ON CHRONIC INFLAMMATION OF THE UVEA. [PDF]

The Lancet
n ...
openaire   +2 more sources

A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with reproductive and metabolic dysfunctions, including gut microbiome dysbiosis.
Fereshteh Esfandiarinezhad, Xiaoshu Zhan, Seang Lin Tan, Julang Li, Benjamin K. Tsang   +4 more
doaj   +1 more source

Platelets in chronic liver disease, from bench to bedside

JHEP Reports, 2019
Summary: In the last decade, numerous studies revealed physiologic and pathophysiologic roles of platelets beyond haemostasis, a process to prevent and stop bleeding.
Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder   +3 more
doaj   +1 more source

The intriguing role of Rifaximin in gut barrier chronic inflammation and in the treatment of Crohn’s disease

, 2018
Introduction: The gastrointestinal tract acts as a functional unit organized as a semipermeable multilayer system, in which commensal gut microbiota represents the anatomical barrier.
Antonio Gasbarrini, Lopetuso, Loris R., Napoli, Marco, Gasbarrini, Antonio, Marco Napoli, Rizzatti, Gianenrico, Gianenrico Rizzatti, Loris R. Lopetuso   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source