Results 61 to 70 of about 3,472,002 (291)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Source of Chronic Inflammation in Aging [PDF]

Frontiers in Cardiovascular Medicine, 2018
Aging is a complex process that results from a combination of environmental, genetic, and epigenetic factors. A chronic pro-inflammatory status is a pervasive feature of aging. This chronic low-grade inflammation occurring in the absence of overt infection has been defined as "inflammaging" and represents a significant risk factor for morbidity and ...
Fumihiro Sanada, Yoshiaki Taniyama, Yoshiaki Taniyama, Jun Muratsu, Jun Muratsu, Rei Otsu, Hideo Shimizu, Hiromi Rakugi, Ryuichi Morishita   +8 more
openaire   +3 more sources

Global DNA methylation signatures associated with chemoresistance and poor prognosis of high grade serous ovarian cancer

Scientific Reports
Ovarian cancer (OVCA) is third most lethal gynecologic cancers and acquired chemoresistance is the key link in the high mortality rate of OVCA patients. Currently, there are no reliable methods to predict chemoresistance in OVCA.
Hafiza Bushra Manzoor, Melisa Acun, Hamed Yasavoli-Sharahi, Chantal Matar, Arvind Mer, Benjamin K. Tsang, Meshach Asare-Werehene   +6 more
doaj   +1 more source

Systematic Review and Meta-Analysis of Intensive Care Unit Scoring Systems’ Performance in Patients with Pre-Existing Kidney Disease

Kidney International Reports
Introduction: Several scoring systems are used to provide prognostic estimates of mortality among patients admitted to the intensive care unit (ICU) but do not account for baseline kidney function.
Hajar El-wadia, Marisha Karim, Amos Buh, Abdulghani O. Kabli, Nandini Biyani, Risa Shorr, Inok Lee, Deena Fremont, Ron Wald, Shane W. English, Samuel A. Silver, Ayub Akbari, Gregory A. Knoll, Edward G. Clark, Gregory L. Hundemer   +14 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Astragaloside IV Alleviates DSS-Induced Ulcerative Colitis by Modulating Host–Gut Tryptophan Metabolism

Foods
Astragaloside IV (AS-IV), a principal bioactive constituent of the medicinal and edible herb Radix astragali, exerts protective effects against ulcerative colitis (UC).
Hongxia Yuan, Zhijun Yang, Chunmei Wu, Xinyu Chen, Lili Peng, Yajie Liu, Xinyi Wang, Yuanbiao Qiao, Fan Yang, Rui Ge, Qingshan Li   +10 more
doaj   +1 more source

Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes

Journal of Neuroinflammation, 2020
Background Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune communication pathways, how the brain senses and responds to peripheral inflammation ...
Carolyn A. Thomson, Alison McColl, Gerard J. Graham, Jonathan Cavanagh   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Minibioreactor arrays to model microbiome response to alcohol and tryptophan in the context of alcohol-associated liver disease

npj Biofilms and Microbiomes
The intestinal microbiota (IM) plays a role in the severity of alcohol-associated liver disease. Modifying severe alcohol-associated hepatitis (AH) dysbiosis improves liver injury through tryptophan (Trp) metabolites and the aryl hydrocarbon receptor ...
Wanchao Hu, Sabrine Naimi, Nicolas Trainel, Vanessa Liévin-Le Moal, Gabriel Perlemuter, Benoit Chassaing, Dragos Ciocan, Anne-Marie Cassard   +7 more
doaj   +1 more source