Results 61 to 70 of about 1,887,624 (306)

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes [PDF]

, 2015
Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation.
Bertolini, Camilla, Fallarino, Mara, Filardi, Tiziana, Gianfrilli, Daniele, Giannetta, Elisa, Lenti, Luisa, Lenzi, Andrea, Lococo, Manuela, Mandosi, Elisabetta, Morano, Susanna, Venneri, MARY ANNA   +10 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Chronic Inflammation in Cancer Development [PDF]

Frontiers in Immunology, 2012
Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth, invasion, and metastatic spread; on the other hand inflammation can stimulate immune effector mechanisms that might limit tumor growth.
Gabriele eMulthoff, Gabriele eMulthoff, Gabriele eMulthoff, Michael eMolls, Jürgen eRadons   +4 more
openaire   +3 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes

Journal of Neuroinflammation, 2020
Background Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune communication pathways, how the brain senses and responds to peripheral inflammation ...
Carolyn A. Thomson, Alison McColl, Gerard J. Graham, Jonathan Cavanagh   +3 more
doaj   +1 more source

Rhegmatogenous retinal detachment masquerading as exudative panuveitis with intense anterior chamber inflammatory reaction. [PDF]

, 2020
Purpose:This is a retrospective case report illustrating the diagnostic and therapeutic challenges associated with a chronic rhegmatogenous retinal detachment masquerading as a severe panuveitis with intense anterior chamber inflammation.
Bhisitkul, Robert B, Gonzales, John A, Joye, Ashlin S, Pereira, Daniel DS   +3 more
core  

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with reproductive and metabolic dysfunctions, including gut microbiome dysbiosis.
Fereshteh Esfandiarinezhad, Xiaoshu Zhan, Seang Lin Tan, Julang Li, Benjamin K. Tsang   +4 more
doaj   +1 more source

Platelets in chronic liver disease, from bench to bedside

JHEP Reports, 2019
Summary: In the last decade, numerous studies revealed physiologic and pathophysiologic roles of platelets beyond haemostasis, a process to prevent and stop bleeding.
Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder   +3 more
doaj   +1 more source

The Expression and Regulation of Chemokines (CXCL9, CXCL10, CXCL11) in Urinary Bladder Inflammation of the Mouse [PDF]

, 2017
Interstitial cystitis is a serious chronic condition that causes bladder pain and increased voiding frequency in millions of adults in the US, most of them women.
Guo, Michael
core   +1 more source