Results 91 to 100 of about 2,740,979 (275)

CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil

Infectious Diseases of Poverty, 2020
Background Chagas disease is endemic in Latin America and still represents an important public health problem in the region. Chronic cardiomyopathy is the most significant chronic form due to its association with morbidity and mortality.
Fernanda Fortes de Araújo, Karen Cecília Lima Torres, Sérgio Viana Peixoto, Antonio Luiz Pinho Ribeiro, Juliana Vaz Melo Mambrini, Vitor Bortolo Rezende, Maria Luiza Lima Silva, Antônio Ignácio Loyola Filho, Andréa Teixeira-Carvalho, Maria Fernanda Lima-Costa, Olindo Assis Martins-Filho   +10 more
doaj   +1 more source

TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013
Recent findings indicate that TLR3 polymorphisms increase susceptibility to enteroviral myocarditis and inflammatory dilated cardiomyopathy (iDCM) in patients. TLR3 signaling has been found to inhibit coxsackievirus B3 (CVB3) replication and acute myocarditis in mouse models, but its role in the progression from myocarditis to iDCM has not been ...
Eric D, Abston, Michael J, Coronado, Adriana, Bucek, Jennifer A, Onyimba, Jessica E, Brandt, J Augusto, Frisancho, Eunyong, Kim, Djahida, Bedja, Yoon-kyu, Sung, Andrea J, Radtke, Kathleen L, Gabrielson, Wayne, Mitzner, DeLisa, Fairweather   +12 more
openaire   +3 more sources

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

CARDIOMYOPATHY IN MALES DRIVEN BY CHRONIC IFN-G EXPOSURE IN A MOUSE MODEL OF AUTOIMMUNE DISEASE

, 2022
Cardiovascular diseases have been associated with a chronic inflammatory response and activated cell-mediated immunity. However, modeling these chronic inflammatory diseases has been difficult. Systemic lupus erythematosus (SLE), a disease that is driven
Fenimore, John Maxwell
core   +1 more source

Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic Myocarditis

JACC: Basic to Translational Science
Echocardiographic imaging mirrors the immunopathological processes underlying the progression from acute myocarditis to inflammatory cardiomyopathy. T cell-mediated myocardial inflammation and edematous swelling in subepicardial regions at disease onset is followed by smoldering low-level myocardial inflammation or increasing cardiomyocyte loss and ...
Anna Joachimbauer, Nadine Cadosch, Cristina Gil-Cruz, Christian Perez-Shibayama, Kira Frischmann, Emily Payne, Isabella Hanka, Micha T. Maeder, Hans Rickli, Felix C. Tanner, Frank Ruschitzka, Burkhard Ludewig, Dörthe Schmidt   +12 more
openaire   +2 more sources

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Chronic phase of Chagas disease: why should it be treated? A comprehensive review

Memorias do Instituto Oswaldo Cruz, 2011
The pathogenesis and evolutive pattern of Chagas disease suggests that the chronic phase should be more widely treated in order to (i) eliminate Trypanosoma cruzi and prevent new inflammatory foci and the extension of tissue lesions, (ii) promote tissue ...
José Rodrigues Coura, José Borges-Pereira   +1 more
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Molecular genetics of arrhythmogenic right ventricular cardiomyopathy in South Africa [PDF]

, 2011
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable disorder characterised by progressive degeneration of the right ventricular myocardium, arrhythmias and an increased risk of sudden death at a young age. Fourteen chromosomal loci have
Blanckenberg, Janine
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source