Results 71 to 80 of about 2,740,979 (275)

Differences in virus prevalence and load in the hearts of patients with chronic dilated cardiomyopathy with and without immune-mediated inflammatory disease [PDF]

Journal of Translational Medicine, 2010
Autoimmune responses against the heart and infections with cardiotropic viruses have been suggested to play a major role in the pathogeneses of idiopathic dilated cardiomyopathy (DCM). The interaction and cross-talk between these complex mechanisms is not completely understood, making etiologic distinction difficult.
Heymans S, Cohen Tervaert J W, Wolffs P, Bruggeman C, van Paassen P, Dennert R   +5 more
openaire   +2 more sources

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Cardio-Immunology of Myocarditis: Focus on Immune Mechanisms and Treatment Options

Frontiers in Cardiovascular Medicine, 2019
Myocarditis and inflammatory cardiomyopathy are syndromes, not aetiological disease entities. From animal models of cardiac inflammation we have detailed insight of the strain specific immune reactions based on the genetic background of the animal and ...
Bernhard Maisch
doaj   +1 more source

Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy

Scientific Reports, 2021
Uremic cardiomyopathy is characterized by diastolic dysfunction (DD), left ventricular hypertrophy (LVH), and fibrosis. Angiotensin-II plays a major role in the development of uremic cardiomyopathy via nitro-oxidative and inflammatory mechanisms.
Zsuzsanna Z. A. Kovács, Gergő Szűcs, Marah Freiwan, Mónika G. Kovács, Fanni M. Márványkövi, Hoa Dinh, Andrea Siska, Katalin Farkas, Ferenc Kovács, András Kriston, Péter Horváth, Bence Kővári, Bálint Gábor Cserni, Gábor Cserni, Imre Földesi, Tamás Csont, Márta Sárközy   +16 more
doaj   +1 more source

Chronic inflammatory cardiomyopathy and its overlap with arrhythmogenic cardiomyopathy: long-term follow-up of a prospective single-centre cohort study [PDF]

Europace
Abstract Background Chronic Inflammatory Cardiomyopathy (infl-CMP) may overlap with Arrhythmogenic Cardiomyopathy (ACM), a group of conditions with similar ventricular arrhythmic phenotypes and key imaging, electrocardiographic, histopathological, and genetic features.
Ballacci, F, Giordano, F, Flore, F, Bencardino, G, Tiziano, F D, D' Alessandris, N, Perna, F, Comerci, G, Pinnacchio, G, Pelargonio, G, Narducci, M L   +10 more
europepmc   +2 more sources

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model [PDF]

, 2008
Inflammatory cardiomyopathy is a common cause of heart failure developing on a basis of cardiac inflammation. Cardiac inflammation - or myocarditis - is usually triggered by infections or cardiac damage of any cause.
Eriksson, Urs, Eriksson, U, Valaperti, A, Valaperti, Alan, Blyszczuk, Przemyslaw, Blyszczuk, P, Błyszczuk, Przemysław   +6 more
core   +1 more source

miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy.

PLoS Neglected Tropical Diseases, 2020
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of cardiomyopathy in Latin America. Although chronic myocarditis
Laurie Laugier, Ludmila Rodrigues Pinto Ferreira, Frederico Moraes Ferreira, Sandrine Cabantous, Amanda Farage Frade, Joao Paulo Nunes, Rafael Almeida Ribeiro, Pauline Brochet, Priscila Camillo Teixeira, Ronaldo Honorato Barros Santos, Edimar A Bocchi, Fernando Bacal, Darlan da Silva Cândido, Vanessa Escolano Maso, Helder I Nakaya, Jorge Kalil, Edecio Cunha-Neto, Christophe Chevillard   +17 more
doaj   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source