Results 61 to 70 of about 2,740,979 (275)

Molecular pathogenetic mechanisms and new therapeutic perspectives in anthracycline-induced cardiomyopathy

Italian Journal of Pediatrics, 2009
Anthracyclines are among the most powerful drugs for the treatment of oncologic diseases both in childhood and in adulthood. Nevertheless, their major antineoplastic efficacy can be seriously impaired by collateral toxic cardiac effects causing ...
Distefano Giuseppe
doaj   +1 more source

Cardiac involvement with anti‐mitochondrial antibody‐positive myositis mimicking cardiac sarcoidosis

ESC Heart Failure, 2020
Anti‐mitochondrial antibody (AMA)‐positive myositis is an atypical inflammatory myopathy characterized by chronic progressive respiratory muscle weakness, muscular atrophy, and cardiac involvement.
Takahide Kadosaka, Shingo Tsujinaga, Hiroyuki Iwano, Kiwamu Kamiya, Azusa Nagai, Yoshifumi Mizuguchi, Ko Motoi, Kazunori Omote, Toshiyuki Nagai, Ichiro Yabe, Toshihisa Anzai   +10 more
doaj   +1 more source

Myocardial Expression of Toll-Like Receptor 4 Predicts the Response to Immunosuppressive Therapy in Patients with Virus-Negative Chronic Inflammatory Cardiomyopathy [PDF]

European Journal of Heart Failure, 2017
Abstract Aims We sought to determine whether myocardial expression of Toll-like receptor 4 (TLR4) may predict the response to immunosuppression. Methods and results Endomyocardial biopsies from 237 patients with virus-
Chimenti C, Verardo R, Scopelliti F, Grande C, Alfarano M, Petrosillo N, Fedele F, Frustaci A.   +7 more
openaire   +5 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Takotsubo Cardiomyopathy in a Patient with Chronic Inflammatory Demyelinating Polyneuropathy [PDF]

, 2015
Takotsubo cardiomyopathy is an acute non-ischemic cardiomyopathy and may be triggered by physical, emotional stress or following excessive catecholamines in the body.  It has been associated with many neurologic conditions.
Kandel, Amit, Gokhale, Rohit, Alfaro-Franco, Carina, Li, Ping, Farooq, Osman, Ching, Marilou   +5 more
core  

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Characteristics of Uremic Cardiomyopathy with Reversible Systolic Dysfunction [PDF]

, 2009
Background: There exists a sub group of patients with uremic cardiomyopathy who experience resolution of heart failure following hemodialysis.
Shamanna Iyengar, Srilakshmi Adhyapak
core  

Analysis of desmoplakin in arrythmogenic right ventricular cardiomyopathy [PDF]

, 2010
Includes bibliographical references (leaves 71-79).It has been shown that all forms of cardiomyopathy, including the dilated, hypertrophic, restrictive, and right ventricular arrhythmogenic forms, are found in African populations.
Fish, Maryam
core   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Personalized medicine in inflammatory cardiomyopathy

, 2018
Inflammatory cardiomyopathy is the result of persistent myocardial inflammation which can arise from both infectious or noninfectious causes. While most patients with acute myocarditis recover, up to 20% develop inflammatory cardiomyopathy with chronic ...
Qifeng Zhou, Michael Gramlich, Balram Neupane, Meinrad Gawaz   +3 more
core   +1 more source