Chronic Inflammatory Cardiomyopathy of Interferon γ–Overexpressing Transgenic Mice Is Mediated by Tumor Necrosis Factor-α [PDF]
The American Journal of Pathology, 2012 We recently described a model of inflammatory cardiomyopathy in interferon (IFN)-γ overexpressing transgenic mice stably circulating IFN-γ in the serum referred to as SAP--IFN-γ mice. SAP-IFN-γ transgenic mice show cardiac infiltration by mononuclear leukocytes, culminating in dilated cardiomyopathy characterized by an increase of left ventricular end ...
Michael, Torzewski +11 more
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The clinical, electrocardiographic and echocardiographic features and long-term outcome of patients with Tachycardia-induced cardiomyopathy [PDF]
, 2010 Includes abstract.Includes bibliographical references.Tachycardia-induced cardiomyopathy (TIC) is a reversible cause of LV systolic dysfunction that can complicate any supraventricular or ventricular tachyarrhythmia.
Chin, Ashley
core +1 more source
Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Revista da Sociedade Brasileira de Medicina TropicalINTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.
Matheus Barbosa de Miranda +5 more
doaj +1 more source
Acute Viral Hepatitis E Is Associated with the Development of Myocarditis
Case Reports in Hepatology, 2015 Myocarditis, an inflammatory disease of heart muscle, is an important cause of dilated cardiomyopathy worldwide. Viral infection is an important cause of myocarditis. This condition presents with various symptoms, ranging from minimally symptomatic cases
M. Premkumar +5 more
doaj +1 more source
Chronic Active Myocarditis and Inflammatory Cardiomyopathy ― Challenges in Diagnosis and Treatment ―
Circulation JournalMyocarditis is a heterogeneous disease with diverse etiologies and clinical trajectories. Traditionally, its diagnosis has been guided by the Dallas criteria, which focus on histopathological features. Clinically, myocarditis is categorized as acute or chronic based on the duration since symptom onset.
Nagai, Toshiyuki +8 more
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A Toolbox of Potential Immune-Related Therapies for Inflammatory Cardiomyopathy [PDF]
, 2020 Myocarditis is a multifactorial disorder, characterized by an inflammatory reaction in the myocardium, predominantly triggered by infectious agents, but also by antigen mimicry or autoimmunity in susceptible individuals.
Tschöpe, Carsten +2 more
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Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Dilated Cardiomyopathy: A New Association? [PDF]
Journal of Cardiology & Cardiovascular Therapy, 2018 n ...
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Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection [PDF]
Vaccines, 2020 Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned TcG2 and TcG4 in a nanovector and evaluated whether nano-immunotherapy (referred as nano2/4) offers resistance to chronic Chagas disease.
Nandadeva Lokugamage +4 more
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Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Dilated cardiomyopathy in childhood [PDF]
, 2000 Dilated Cardiomyopathy is an uncommon disease in children but morbidity and mortality in affected patients are high. This review discuses clinical presentation, diagnosis, medical management and prognosis of the condition, with an emphasis on recent ...
Franklin, O.M.
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