Results 241 to 250 of about 6,876,919 (290)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Chronic Kidney Disease-Associated Pruritus in Patients on Home Haemodialysis. [PDF]

Nephrology (Carlton)
Nayak KK, Goh JX, Sud K, Tarafdar S, Do LL, Bhimani N, Thunga G, Castelino RL.   +7 more
europepmc   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

The Impact of Chronic Kidney Disease on Oral Health: A Narrative Review. [PDF]

J Clin Med
Kes PM, Krndelj A, Jurić S, Hadžović E, Bašić Jukić N, Brailo V.   +5 more
europepmc   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

Quantifying inequalities and forecasting the burden of chronic kidney disease from 1990 to 2040. [PDF]

iScience
Shao X, Jin W, Pang M, Chen R, Luo T, Zhang H, Pan L, Ding K, Ma S, Zheng L, Huang B, Ye P, Nie S, Xu X, Lin Q.   +14 more
europepmc   +1 more source

Hypertension in chronic kidney disease: where do international guidelines converge and diverge? [PDF]

Clin Hypertens
Stambolliu E, Stathopoulou E, Bora M, Damianaki A.   +3 more
europepmc   +1 more source

Vaccination of Patients with Chronic Kidney Disease and Cocooning Strategy in a Tertiary Hospital. [PDF]

Vaccines (Basel)
Michailou M, Bitsori M, Stylianou K, Kofteridis D, Blevrakis E, Dimitriou R, Zacharioudaki M, Galanakis E.   +7 more
europepmc   +1 more source

Protein mediators of chronic kidney disease in Type 2 diabetes: A mendelian randomization study. [PDF]

PLoS Med
Liang KYH, Zheng TM, Tan D, Sasako T, Ilboudo Y, Chen Y, Butler-Laporte G, Yoshiji S, Richards JB.   +8 more
europepmc   +1 more source