Results 71 to 80 of about 855,465 (305)

The role of sacubitril/valsartan in abnormal renal function patients combined with heart failure: a meta-analysis and systematic analysis

Renal Failure
Aims This study aimed to investigate the efficacy and safety of sacubitril/valsartan in abnormal renal function (eGFR < 60 ml/min/1.73m2) patients combined with heart failure based on randomized controlled trials (RCTs) and observational studies.Methods ...
Xinyue Yang, Jingjing Jin, Meijuan Cheng, Jinsheng Xu, Yaling Bai   +4 more
doaj   +1 more source

Erratum: Evans M, Grams ME, Sang Y, et al., for the Chronic Kidney Disease Prognosis Consortium. Risk factors for prognosis in patients with severely decreased GFR. Kidney Int Rep. 2018;3:625-637.

, 2022
[This corrects the article DOI: 10.1016/j.ekir.2018.01.002.]
Chronic Kidney Disease Prognosis Consortium
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization

Discover Oncology
Objective Observational studies have yielded inconsistent findings on the relationship between chronic kidney disease (CKD) and the risk of colorectal cancer (CRC).
Shuyi Qian, Yuting Gong, Ying Chen
doaj   +1 more source

IgG4 Autoantibodies Attenuate Systemic Lupus Erythematosus Progression by Suppressing Complement Consumption and Inflammatory Cytokine Production

Frontiers in Immunology, 2020
Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains ...
Qingjun Pan, Haiyan Xiao, Lei Shi, Yiming He, Jun Cai, Jing Wu, Aifen Li, Lin Ye, Chen Yang, Hua-feng Liu   +9 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The spatial analysis of diagnosed Chronic Kidney Disease in Nigeria: A case study of Edo State [PDF]

, 2012
The thesis explores the severity of diagnosed chronic kidney disease (CKD) with particular reference to its impact in Edo state, Nigeria. There has been a scarcity of studies on the prevalence and spatial patterns of CKD in developing countries even ...
Oviasu, Osaretin
core  

Effect of information and telephone-guided access to community support for people with chronic kidney disease: randomised controlled trial

, 2014
BackgroundImplementation of self-management support in traditional primary care settings has proved difficult, encouraging the development of alternative models which actively link to community resources.
Peter Bower (52501), Christian Blickem, Christian Blickem (397641), Brooks Helen, Anne Rogers, Chew-Graham, C, Blakeman, T, Gerry Richardson (571072), Bower, P, David Reeves, Reeves, Davd, Blakeman, Tom, Dawson, S, Gaffney, H, Lee, V, David Reeves (164641), Mossabir Rahena, Tom Blakeman, Hannah Gaffney, Gardner Caroline, Reeves, D, Blickem, C, Victoria Lee, Bower, Peter; id_orcid, Hannah Gaffney (645995), Ivaylo Vassilev (397639), Blickem, Christian, Spackman, E, Anne Kennedy (397644), Victoria Lee (645997), Richardson, Gerry, Shoba Dawson (645999), Dawson Shoba, Helen Brooks (397642), Anne Rogers (397640), Mossabir, Rahena, Spackman, Eldon, Jariwala, P, Spackman Eldon, Shoba Dawson, Blakeman Tom, Gaffney Hannah, Gaffney, Hannah, Anne Kennedy, Praksha Jariwala, Mossabir, R, Vassilev Ivaylo, Chew-Graham Carolyn, Kennedy, A, Dawson, Shoba, Rahena Mossabir (646000), Vassilev, Ivaylo, Reeves, David, Helen Brooks, Praksha Jariwala (645998), Bower Peter, Richardson, G, Caroline Gardner, Jariwala Praksha, Brooks, Helen, Rogers, A, Reeves David, Caroline Gardner (645996), Brooks, H, Kennedy, Anne P., Peter Bower, Bower, Peter, Lee, Victoria, Carolyn Chew-Graham, Blakeman, Tom; id_orcid, Tom Blakeman (645994), Blickem Christian, Lee Victoria, Eldon Spackman, Rogers, Anne, Kennedy, Anne, Gardner, Caroline, Rogers Anne, Ivaylo Vassilev, Eldon Spackman (462402), Richardson Gerry, Gardner, C, Vassilev, I, Kennedy Anne, Rahena Mossabir, Jariwala, Praksha, Chew-Graham, Carolyn, Gerry Richardson, Carolyn Chew-Graham (615627)   +88 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Chronic Anticoagulation in Chronic Kidney Disease∗

Journal of the American College of Cardiology, 2014
Bleeding in patients with chronic kidney disease (CKD) or “uremic bleeding” is a well-recognized complication. It has been described as far back as 1907 by Reisman [(1)][1], classically as a complication of Bright disease.
Ball, Timothy, Wheelan, Kevin, McCullough, Peter A.   +2 more
openaire   +2 more sources