Results 61 to 70 of about 6,876,919 (290)

Identifying potential biomarkers for type 2 diabetes in the adipose tissue of older adults via multiple machine learning algorithms

Scientific Reports
Age-related decline in adipose tissue function is closely associated with impaired insulin sensitivity and chronic low-grade inflammation, and these conditions contribute to type 2 diabetes (T2D) development in older adults.
Yun-Sang Yu, Da Som Lee, Joo Hyun Lim, Yoo Jeong Lee   +3 more
doaj   +1 more source

Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy

Renal Failure
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Mitochondrial dysfunction in the kidney caused by diabetes has previously been linked to the pathogenesis of DN.
Yang Liu, Rong Wu, Zhelun Zhou, Junan Zhou, Jiaai Zhang, Xiaoyi Wang   +5 more
doaj   +1 more source

Research progress on endoplasmic reticulum homeostasis in kidney diseases

Cell Death and Disease, 2023
The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and subcellular organelle crosstalk. Dysregulation of ER homeostasis can cause toxic protein
Dan Wu, Li-Feng Huang, Xiao-Cui Chen, Xiao-Rong Huang, Hui-Yuan Li, Ning AN, Ji-Xin Tang, Hua-Feng Liu, Chen Yang   +8 more
doaj   +1 more source

Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway

Lupus Science and Medicine, 2022
Objective Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation.Methods
Dan Wu, Chen Yang, Xiao-cui Chen, Hong-luan Wu, Hui-yuan Li, Hong-yong Su, Ze-jian Liu, Xiao-rong Huang, Xing Lu, Li-feng Huang, Shao-ping Zhu, Qing-jun Pan, Ning An, Hua-feng Liu   +13 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comparative efficacy of sodium thiosulfate, bisphosphonates, and cinacalcet for the treatment of vascular calcification in patients with haemodialysis: a systematic review and network meta-analysis

BMC Nephrology
Background Up to now, there is no unequivocal intervention to mitigate vascular calcification (VC) in patients with hemodialysis. This network meta-analysis aimed to systematically evaluate the clinical efficacy of sodium thiosulfate, bisphosphonates ...
Lei He, Yuzhe Li, Jingjing Jin, Meijuan Cheng, Yaling Bai, Jinsheng Xu   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of information and telephone-guided access to community support for people with chronic kidney disease: randomised controlled trial [PDF]

, 2014
BackgroundImplementation of self-management support in traditional primary care settings has proved difficult, encouraging the development of alternative models which actively link to community resources.
Peter Bower (52501), Christian Blickem, Christian Blickem (397641), Brooks Helen, Anne Rogers, Chew-Graham, C, Blakeman, T, Gerry Richardson (571072), Bower, P, David Reeves, Reeves, Davd, Blakeman, Tom, Dawson, S, Gaffney, H, Lee, V, David Reeves (164641), Mossabir Rahena, Tom Blakeman, Hannah Gaffney, Gardner Caroline, Reeves, D, Blickem, C, Victoria Lee, Bower, Peter; id_orcid, Hannah Gaffney (645995), Ivaylo Vassilev (397639), Blickem, Christian, Spackman, E, Anne Kennedy (397644), Victoria Lee (645997), Richardson, Gerry, Shoba Dawson (645999), Dawson Shoba, Helen Brooks (397642), Anne Rogers (397640), Mossabir, Rahena, Spackman, Eldon, Jariwala, P, Spackman Eldon, Shoba Dawson, Blakeman Tom, Gaffney Hannah, Gaffney, Hannah, Anne Kennedy, Praksha Jariwala, Mossabir, R, Vassilev Ivaylo, Chew-Graham Carolyn, Kennedy, A, Dawson, Shoba, Rahena Mossabir (646000), Vassilev, Ivaylo, Reeves, David, Helen Brooks, Praksha Jariwala (645998), Bower Peter, Richardson, G, Caroline Gardner, Jariwala Praksha, Brooks, Helen, Rogers, A, Reeves David, Caroline Gardner (645996), Brooks, H, Kennedy, Anne P., Peter Bower, Bower, Peter, Lee, Victoria, Carolyn Chew-Graham, Blakeman, Tom; id_orcid, Tom Blakeman (645994), Blickem Christian, Lee Victoria, Eldon Spackman, Rogers, Anne, Kennedy, Anne, Gardner, Caroline, Rogers Anne, Ivaylo Vassilev, Eldon Spackman (462402), Richardson Gerry, Gardner, C, Vassilev, I, Kennedy Anne, Rahena Mossabir, Jariwala, Praksha, Chew-Graham, Carolyn, Gerry Richardson, Carolyn Chew-Graham (615627)   +88 more
core   +1 more source

Chronic Anticoagulation in Chronic Kidney Disease∗

Journal of the American College of Cardiology, 2014
Bleeding in patients with chronic kidney disease (CKD) or “uremic bleeding” is a well-recognized complication. It has been described as far back as 1907 by Reisman [(1)][1], classically as a complication of Bright disease.
Ball, Timothy, Wheelan, Kevin, McCullough, Peter A.   +2 more
openaire   +2 more sources

Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization

Discover Oncology
Objective Observational studies have yielded inconsistent findings on the relationship between chronic kidney disease (CKD) and the risk of colorectal cancer (CRC).
Shuyi Qian, Yuting Gong, Ying Chen
doaj   +1 more source