Results 51 to 60 of about 596,348 (255)

Targeting MCL1 by UMI-77 to induce mitophagy alleviates renal tubular epithelial cells injury in acute kidney injury

Scientific Reports
Acute kidney injury (AKI) is a common clinical disease with complex pathophysiological processes and with high morbidity and mortality. Severe mitochondrial damages, such as mitochondrial swelling and fragmentation, disruption of membrane integrity, and ...
Xiaoyu Li, Zixian Li, Yongming Chen, Hongluan Wu, Yonghan Liu, Zhennan Ye, Qingqing Yang, Haicha Hou, Junfeng Hao, Ruigao Song, Huafeng Liu   +10 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Determining the frequency of Helicobacter pylori in children with chronic kidney failure and its relationship to gastrointestinal symptoms

Clinical Case Reports
Key Clinical Message As there is no significant mutual relationship between Helicobacter pylori infection and chronic kidney disease in children, its routine study is not justified and is recommended only in symptomatic cases. Abstract Children suffering
Behgol Nemati Nezhad, Bahar Allahverdi, Farzaneh Motamed, Shirin Djalalinia, Fahimeh Askarian, Daryoush Fahimi, Behnaz Bazargani, Arash Abbasi, Mastaneh Moghtaderi   +8 more
doaj   +1 more source

Endoplasmic reticulum stress within the primary motor cortex in hypobaric hypoxia-induced acute urinary retention

IBRO Neuroscience Reports
Purpose: Acute urinary retention (AUR) is a prevalent clinical challenge following rapid exposure to hypobaric hypoxia (HH). Neurons are highly sensitive to HH, and the destruction or damage of primary motor cortex (M1) neurons will lead to micturition ...
Quanchao Zhang, Yingying Ma, Caibao Lu, Ling Nie, Hongwei Chen, Jiujian Cao, Jinghong Zhao, Yinghui Huang   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

odd skipped-related 2 as a novel mark for labeling the proximal convoluted tubule within the zebrafish kidney

Heliyon
The proximal convoluted tubule (PCT) of the kidney is a crucial functional segment responsible for reabsorption, secretion, and the maintenance of electrolyte and water balance within the renal tubule.
Wenmin Yang, Xiaoliang Liu, Zhongwei He, Yunfeng Zhang, Xiaoqin Tan, Chi Liu   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The microbial metabolite trimethylamine N-oxide and the kidney diseases

Frontiers in Cellular and Infection Microbiology
Trimethylamine N-oxide (TMAO), a metabolite, is a co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carnitine.
Jin-Qi Su, Jin-Qi Su, Xiang-Qi Wu, Xiang-Qi Wu, Qi Wang, Qi Wang, Bo-Yang Xie, Bo-Yang Xie, Cui-Yan Xiao, Cui-Yan Xiao, Hong-Yong Su, Hong-Yong Su, Ji-Xin Tang, Ji-Xin Tang, Cui-Wei Yao, Cui-Wei Yao   +15 more
doaj   +1 more source

Sphingolipids and Chronic Kidney Disease

Journal of Clinical Medicine
Sphingolipids (SLs) are bioactive signaling molecules essential for various cellular processes, including cell survival, proliferation, migration, and apoptosis. Key SLs such as ceramides, sphingosine, and their phosphorylated forms play critical roles in cellular integrity. Dysregulation of SL levels is implicated in numerous diseases, notably chronic
Zrinka Šakić, Armin Atić, Slavica Potočki, Nikolina Bašić-Jukić   +3 more
openaire   +2 more sources

Cardiovascular disease in chronic kidney disease

Therapeutic Advances in Cardiovascular Disease, 2008
The presence of kidney disease, manifested by low glomerular filtration rates (GFR) and/or large amounts of protein in the urine, is independently associated with increased rates of cardiovascular disease (CVD). The severity of kidney disease is associated with graded increases in risk for CVD and death.
Anita M, Saran, Thomas D, DuBose
openaire   +2 more sources