Results 131 to 140 of about 2,356,863 (206)

Ursodeoxycholic Acid Confers Neuroprotection in Rats With Acute Cervical SCI and Attenuates NLRP3/Caspase‐1/GSDMD Pyroptotic Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Ursodeoxycholic Acid could inhibit activation of the NLRP3/Caspase‐1/GSDMD pyroptosis pathway and reduce the release of downstream inflammatory cytokines IL‐18 and IL‐1β in rats with acute C5 cervical SCI. This modulation is associated with attenuated secondary injury and improved functional outcomes.
Honghu Song, Xiaomin Hu, Dan Liu, Linjie Wang, Li Zhu, Wenchun Wang, Rongnan Hu, Jiayan Zhong, Jiancheng Liu, Rizhao Pang, Anren Zhang   +10 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

A 5-year limb salvage for long-term limb salvage in chronic limb-threatening ischemia without options for revascularization, utilizing a hybrid deep venous arterialization technique: A case report

Science Progress
Chronic limb-threatening ischemia represents the most severe form of peripheral arterial disease, with a 40% amputation rate and 20% mortality at 6 months without revascularization. Deep venous arterialization is an alternative for patients with advanced
Lucas Ferrer, Lynsey Malin, Panagiotis Koutakis, Dimitrios Miserlis   +3 more
doaj   +1 more source

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real‐Life Experience From a National Reference Network

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10318-10329, November 2026.
ABSTRACT Aim Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy. Patients and Methods Patients with familial partial lipodystrophy (n = 57) or congenital generalised ...
Léna Robert, Ines Belalem, Corinne Vigouroux, Hippolyte Dupuis, Marie Christine Vantyghem, Mathilde Simonson, Estelle Nobecourt, Héléna Mosbah, Sophie Beliard, Stéphanie Jellimann, Sonja Janmaat, Camille Vatier, Sophie Lamothe   +12 more
wiley   +1 more source

“Life and Lower Limb Threatening Condition” Clinical Features, Management and Outcomes of Diabetic Foot Ulcers Complicated by Gas Gangrene: A Prospective Cohort Study

International Wound Journal, Volume 23, Issue 11, November 2026.
ABSTRACT Diabetic foot ulcer (DFU) is a common complication of diabetes in low‐ and middle‐income countries and may be complicated by gas gangrene (GG), a rapidly progressive, life‐threatening infection. This prospective study assessed whether GG can be diagnosed clinically in low‐resource primary care and explored factors associated with wound‐healing
Zulfiqarali G. Abbas, Raidah R. Gangji, Roozbeh Naemi   +2 more
wiley   +1 more source

Accelerated Preoperative Wound Bed Preparation Using Negative Pressure Wound Therapy With Instillation and Dwell Time: A Comparison With Conventional Negative Pressure Wound Therapy in Necrotic Wounds

International Wound Journal, Volume 23, Issue 11, November 2026.
ABSTRACT Negative pressure wound therapy with instillation and dwell time (NPWTi‐d) and conventional NPWT are established treatments for complex wounds, yet direct comparative evidence remains limited. This retrospective observational study evaluated the clinical effectiveness of NPWTi‐d for hard‐to‐heal necrotic wounds using standardized parameters ...
Norihiko Ohura, Daisuke Nakayama, Mikio Kinoshita, Tomohide Shiraishi, Yuki Morishige, Shungo Murai, Mine Ozaki   +6 more
wiley   +1 more source

Drug-Coated Devices, Wound Healing, and Mortality After Endovascular Therapy for Chronic Limb-Threatening Ischemia

Background: The clinical benefit and safety of drug-coated devices in chronic limb-threatening ischemia remain debated, particularly after recent randomized evidence questioning paclitaxel-coated technologies.
Ivan Walton, Yonggu Lee, Oliver Schlager, Charlotte Allan, Christian Heiss, Marianne Brodmann, Gary D Maytham, Alexander D Rodway, Jenny Harris, Nikolaos Ntagiantas, Felipe Pazos-Casal   +10 more
core   +1 more source

Circulating Natural Killer Cells in Patients With Type 2 Diabetes and Peripheral Neuropathy Are Altered in Their Frequency and Exhibit Impaired Functions and Angiogenic Activities

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Neuropathic T2DM is characterized by increased circulating NK‐cell frequency but impaired NK‐cell function. Functional defects, including reduced degranulation and diminished pro‐angiogenic activity, together with an inflammatory cytokine milieu, promote macrophage recruitment, vascular inflammation, and defective angiogenesis, highlighting NK‐cell ...
Maria Teresa Palano, Federica Riccio, Luisa Sambado, Elena Tagliabue, Milena Bertolotti, Marzia Campanile, Martina Mutoli, Fiorenza Lotti, Andrea Rampin, Cristian Rubuano, Giorgia Maspero, Antonio Antico, Francesca Pitzalis, Matteo Fassan, Piero Maria Stefani, Paola Ostano, Giovanna Chiorino, Nicolò Baranzini, Laura Pulze, Annalisa Grimaldi, Antonino Bruno, Maria Sambataro, Gaia Spinetti   +22 more
wiley   +1 more source

Exploring the Mechanism of Postpartum Cognitive Dysfunction in a Preeclampsia Rat Model via Multimodal Imaging

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
This schematic illustrates an L‐NAME‐induced preeclampsia (PE) rat model generated via L‐NAME administration to pregnant dams, wherein Morris water maze assessments confirmed progressive postpartum cognitive dysfunction that emerged at 10 days post‐partum and deteriorated further at 1 and 3 months post‐partum. Multimodal magnetic resonance imaging (MRI)
Yong Xia, Junguo Zhao, Bo Gao
wiley   +1 more source

Anatomical Predictors of Endovascular Technical Success in Chronic Limb-Threatening Ischemia: The Role of GLASS and Diabetes. [PDF]

Med Sci (Basel)
Dumitrescu-Bordianu A, Baroi LG, Popa RF, Iacob L, Caba B, Morariu PC, Godun MM, Caba IC, Petrariu F, Knieling A, Huzum B, Nedelcu AH, Floria M.   +12 more
europepmc   +1 more source