Results 121 to 130 of about 2,356,865 (206)

Stem Cell Therapy in No Option Chronic Limb-threatening Ischemia

Indian Journal of Vascular and Endovascular Surgery
Introduction: Chronic limb-threatening ischemia (CLTI) leads to limb loss in 50% of patients with 20% mortality within 1 year. Patients with advanced disease eventually require major amputation despite currently available revascularization technologies ...
Yashshwini B Kareti, Vinay Kumar, Sanjay C Desai, Chandrashekar Anagavalli Ramswamy, Suhas S Gowda   +4 more
doaj   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Narrative Review of Biological Markers in Chronic Limb-Threatening Ischemia

Biomedicines
Background: Chronic limb-threatening ischemia (CLTI), the advanced stage of peripheral arterial disease, is diagnosed in the presence of ischemic rest pain, non-healing ulcers, or gangrene.
Alexandra Ioana Popescu, Andreea Luciana Rata, Sorin Barac, Roxana Popescu, Roxana Ramona Onofrei, Cristian Vlad, Daliborca Vlad   +6 more
doaj   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Characteristics and Outcomes After General Anaesthesia in Elderly Patients: A Nationwide Cohort Study

Acta Anaesthesiologica Scandinavica, Volume 71, Issue 1, January 2027.
ABSTRACT Background Elderly patients are more frail and have a higher burden of comorbidity, which could influence the risk of complications after anaesthesia. The aim of this study was to describe the elderly patient population undergoing general anaesthesia in Denmark.
Benjamin H. Risager, Signe Ø. Mortensen, Maria B. Pælestik, Nikola Stankovic, Peter C. Lind, Lars W. Andersen   +5 more
wiley   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Efficacy of Aspirin and Low-Dose Rivaroxaban in Chronic Limb-Threatening Ischemia Under Different Comorbid Conditions

Background: Chronic limb-threatening ischemia (CLTI) in patients with diabetic angiopathy and peripheral atherosclerotic disease is associated with severe thrombotic burden, endothelial dysfunction, impaired distal perfusion, and high risk of restenosis ...
Abramishvili, Davit, Gobejishvili, Manana, Popkhadze, Irakli, Lazishvili, Teona, Mosiava, Teimuraz   +4 more
core   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Chronic Limb Threatening Ischemia masquerading as Vitamin D deficiency; A case report

Saudi Journal of Emergency Medicine
Introduction: Limb Ischemia is an uncommon but high risk emergency. It mostly presents as a painful limb in patients with peripheral arterial disease with risk factors such as hypertension, diabetes, smoking and chronic kidney disease. Timely diagnosis
Sarah Afzal Kothari, Hadia Iftikhar, Iqra Anis   +2 more
doaj   +1 more source