Results 11 to 20 of about 819,215 (267)

Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS

Thoracic Cancer, 2023
Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole ...
Mengming Xia, Xueyi Song, Zebei Lu, Yu Wang, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yunfang Zhou, Qingjun Wu, Aixia Han   +9 more
doaj   +1 more source

Increased INR Values Predict Accelerating Deterioration and High Short-Term Mortality Among Patients Hospitalized With Cirrhosis or Advanced Fibrosis

Frontiers in Medicine, 2021
Background and Objective: An increase in the international normalized ratio (INR) is associated with increased mortality in patients with cirrhosis and other chronic liver diseases, while little is known about the quantitative relationship.
Ying Wang, Ying Wang, Fuchen Dong, Fuchen Dong, Shuning Sun, Shuning Sun, Xianbo Wang, Xianbo Wang, Xin Zheng, Xin Zheng, Yan Huang, Yan Huang, Beiling Li, Beiling Li, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Junping Liu, Junping Liu, Haotang Ren, Haotang Ren, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Guohong Deng, Guohong Deng, Liang Qiao, Liang Qiao, Yan Zhang, Yan Zhang, Wenyi Gu, Wenyi Gu, Xiaomei Xiang, Xiaomei Xiang, Yi Zhou, Yi Zhou, Baoyan Xu, Baoyan Xu, Yixin Hou, Yixin Hou, Qun Zhang, Qun Zhang, Yan Xiong, Yan Xiong, Congcong Zou, Congcong Zou, Jun Chen, Jun Chen, Zebing Huang, Zebing Huang, Xiuhua Jiang, Xiuhua Jiang, Tingting Qi, Tingting Qi, Sen Luo, Sen Luo, Yuanyuan Chen, Yuanyuan Chen, Na Gao, Na Gao, Chunyan Liu, Chunyan Liu, Wei Yuan, Wei Yuan, Xue Mei, Xue Mei, Jing Li, Jing Li, Tao Li, Tao Li, Rongjiong Zheng, Rongjiong Zheng, Xinyi Zhou, Xinyi Zhou, Weituo Zhang, Weituo Zhang, Hai Li, Hai Li, Zhongji Meng, Zhongji Meng   +85 more
doaj   +1 more source

CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway

Journal of Translational Medicine, 2023
Background Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence.
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang   +7 more
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Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis

Frontiers in Medicine, 2021
Background: Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients.Methods: We ...
Jing Liu, Jing Liu, Hai Li, Hai Li, Jie Xia, Jie Xia, Xianbo Wang, Xianbo Wang, Yan Huang, Yan Huang, Beiling Li, Beiling Li, Zhongji Meng, Zhongji Meng, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Junping Liu, Junping Liu, Guohong Deng, Guohong Deng, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Liang Qiao, Liang Qiao, Xiaomei Xiang, Xiaomei Xiang, Qun Zhang, Qun Zhang, Ruochan Chen, Ruochan Chen, Jinjun Chen, Jinjun Chen, Sen Luo, Sen Luo, La Gao, La Gao, Liujuan Ji, Liujuan Ji, Jing Li, Jing Li, Xinyi Zhou, Xinyi Zhou, Haotang Ren, Haotang Ren, Sihong Lu, Sihong Lu, Sumeng Li, Sumeng Li, Weituo Zhang, Xin Zheng, Xin Zheng   +58 more
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Cannabinoids and Chronic Liver Diseases

International Journal of Molecular Sciences, 2022
Nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease (ALD), and viral hepatitis are the main causes of morbidity and mortality related to chronic liver diseases (CLDs) worldwide. New therapeutic approaches to prevent or reverse these liver disorders are thus emerging.
Ralph-Sydney Mboumba Bouassa, Giada Sebastiani, Vincenzo Di Marzo, Mohammad-Ali Jenabian, Cecilia T. Costiniuk   +4 more
openaire   +2 more sources

Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK

Cell Death Discovery, 2023
HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear.
Xuesong Cen, Yuyan Lu, Jing Lu, Changhong Luo, Ping Zhan, Yizhe Cheng, Fan Yang, Chengrong Xie, Zhenyu Yin, Fuqiang Wang   +9 more
doaj   +1 more source

The Circulating miRNA Profile of Chronic Hepatitis D and B Patients Is Comparable but Differs from That of Individuals with HBeAg-Negative HBV Infection

Viruses, 2023
miRNAs circulating in whole serum and HBsAg-particles are differentially expressed in chronic hepatitis B (CHB) and HBeAg-negative-HBV infection (ENI); their profiles are unknown in chronic hepatitis D (CHD).
Daniela Cavallone, Eric David B. Ornos, Gabriele Ricco, Filippo Oliveri, Barbara Coco, Piero Colombatto, Laura De Rosa, Leslie Michelle M. Dalmacio, Ferruccio Bonino, Maurizia Rossana Brunetto   +9 more
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The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice

Frontiers in Immunology, 2019
Activation of the innate immune system, including tissue macrophages and associated neutrophil infiltration, is an important driver of subsequent adaptive immune responses in many autoimmune diseases, including autoimmune hepatitis (AIH).
Wagdi Almishri, Abdel Aziz Shaheen, Keith A. Sharkey, Mark G. Swain   +3 more
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Opportunities and Challenges of Surveillance for Liver Cancer in Primary Care Institutions in China [PDF]

Zhongguo quanke yixue, 2023
Primary liver cancer (PLC) is one of the common malignant tumors and the main causes of tumor death in China. Although the diagnosis and treatment technology of PLC in China has made great progress in recent years, its morbidity and mortality have been ...
WANG Shiyue, DONG Chen, CHANG Chudi, NAN Yuemin
doaj   +1 more source

Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B

Molecular Therapy: Nucleic Acids, 2017
Long noncoding RNAs (lncRNAs) are a new class of regulatory noncoding RNAs. Emerging evidences indicate that lncRNAs play a critical role in the development of hepatocellular carcinoma (HCC).
Cheng-Rong Xie, Fei Wang, Sheng Zhang, Fu-Qiang Wang, Sen Zheng, Zhao Li, Jie Lv, He-Qiang Qi, Qin-Liang Fang, Xiao-Min Wang, Zhen-Yu Yin   +10 more
doaj   +1 more source