Results 131 to 140 of about 690,557 (312)

Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases

, 2011
Patients with chronic liver diseases (CLD) including chronic hepatitis B (CHB) and hepatic cirrhosis (CIR) are major high risk population of hepatocellular carcinoma (HCC). And the differential diagnosis between CLD and HCC is a challenge.
陈世礼, 周丽娜, QuancaiWang, 许国旺, 林晓惠, 尹沛源, WenbinXing, 吴泽明, 路鑫, YongZhang   +9 more
core  

Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models

npj Gut and Liver
Hepatocellular carcinoma (HCC), the third cause of cancer-related deaths worldwide, continues to present significant therapeutic challenges. Despite significant therapeutic advancement in the last decade, the efficacy of systemic treatments for patients ...
Romain Desert, Fabio Gianonne, Antonio Saviano, Yujin Hoshida, Mathias Heikenwälder, Pierre Nahon, Thomas F. Baumert   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases

, 2012
Patients with chronic liver diseases (CLD) including chronic hepatitis B and hepatic cirrhosis (CIR) are the major high-risk population of hepatocellular carcinoma (HCC). The differential diagnosis between CLD and HCC is a challenge.
许国旺, Lin, Xiaohui, Wang, Quancai, Yin, Peiyuan, 林晓慧, Lu, Xin, Xing, Wenbin, Zhou, Lina, Chen, Shili, Wu, Zeming, Zhang, Yong, Xu, Guowang   +11 more
core   +1 more source

Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway

BMC Cancer
Background Ribosomal RNA processing protein 15 (RRP15) has been found to regulate the progression of hepatocellular carcinoma (HCC). Nevertheless, the extent to which it contributes to the spread of HCC cells remains uncertain.
Tongtong Pan, Jinhai Li, Ouyang Zhang, Yuqin Zhu, Hongfei Zhou, Mengchen Ma, Yanwen Yu, Jiaojian Lyu, Yongping Chen, Liang Xu   +9 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Pharmacological considerations in pharmacotherapy of rheumatology patients with liver disease: a brief narrative review

Rheumatology
The presence of chronic liver diseases such as metabolic dysfunction-associated steatosis liver disease, viral hepatitis, and cirrhosis may affect the treatment plan in patients with rheumatologic disorders, with concern about the adverse effects of the ...
Saeedeh Shenavandeh, Seyed Alireza Taghavi, AliAkbar Nekooeian, Maryam Moini   +3 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Autonomic and sensory nerve dysfunction in primary biliary cirrhosis

, 2004
AIM: Cardiovascular autonomic and peripheral sensory neuropathy is a known complication of chronic alcoholic and non-alcoholic liver diseases. We aimed to assess the prevalence and risk factors for peripheral sensory nerve and autonomic dysfunction using
Horváth, Andrea, Lakatos, Péter László, Csák, Tímea, Szalay, Ferenc, Istenes, Ildikó, Varga, Péter, Kempler, Péter, Keresztes, Katalin, Folhoffer, Anikó   +8 more
core  

Chronic cholestatic liver diseases [PDF]

Journal of Gastroenterology and Hepatology, 2002
openaire   +2 more sources