Results 31 to 40 of about 2,734,758 (393)

Transcriptional re-programming of insulin B-chain epitope-specific T-follicular helper cells into anti-diabetogenic T-regulatory type-1 cells

Frontiers in Immunology, 2023
Systemic delivery of nanoparticles (NPs) coated with mono-specific autoimmune disease-relevant peptide-major histocompatibility complex class II (pMHCII) molecules can resolve organ inflammation in various disease models in a disease-specific manner ...
Patricia Solé, Daniel Parras, Jun Yamanouchi, Josep Garnica, Nahir Garabatos, Joel Moro, Javier Montaño, Debajyoti Mondal, César Fandos, Yang Yang, Yang Yang, Pau Serra, Pere Santamaria, Pere Santamaria   +13 more
doaj   +1 more source

Pediatric liver diseases: current challenges and future perspectives [PDF]

, 2015
Chronic liver diseases in children represent a rising problem with significant effects on public health. In fact, several pediatric liver diseases are precursors of adult chronic hepatopathies, cirrhosis and hepatocellular carcinoma.
Alisi, Anna, Alterio, Arianna, Della Corte, Claudia, Mosca, Antonella, Nobili, Valerio, Vania, Andrea   +5 more
core   +1 more source

Hydrogen Sulfide Protects Against Ammonia-Induced Neurotoxicity Through Activation of Nrf2/ARE Signaling in Astrocytic Model of Hepatic Encephalopathy

Frontiers in Cellular Neuroscience, 2020
Objective: Hepatic encephalopathy (HE) characterized by neuropsychiatric abnormalities is a major complication of cirrhosis with high mortality. However, the pathogenesis of HE has not been fully elucidated.
Xiaozhi Jin, Dazhi Chen, Faling Wu, Lei Zhang, Yu Huang, Zhuo Lin, Xiaodong Wang, Rui Wang, Lanman Xu, Lanman Xu, Yongping Chen   +10 more
doaj   +1 more source

Heat shock protein HSPA13 promotes hepatocellular carcinoma progression by stabilizing TANK

Cell Death Discovery, 2023
HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear.
Xuesong Cen, Yuyan Lu, Jing Lu, Changhong Luo, Ping Zhan, Yizhe Cheng, Fan Yang, Chengrong Xie, Zhenyu Yin, Fuqiang Wang   +9 more
doaj   +1 more source

YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]

, 2019
Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura, Battistelli, Cecilia, Cicchini, Carla, Consalvi, Veronica, Cozzolino, Angela Maria, Marchetti, Alessandra, Noce, Valeria, Strippoli, Raffaele, Tripodi, Marco   +8 more
core   +1 more source

Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]

, 1988
A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Ballardini, Baum, Berg, Bernuau, Demetris, Demetris, Demetris, Demetris, Detre, Epstein, Epstein, Esquivel, Fennell, Fung, Haagsma, Iwatsuki, James, MacSween, McFarlane, McFarlane, Neuberger, Popper, Portmann, Portmann, Portmann, Vento   +25 more
core   +1 more source

Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C

World Journal of Gastroenterology, 2020
At present chronic liver disease (CLD), the third commonest cause of premature death in the United Kingdom is detected late, when interventions are ineffective, resulting in considerable morbidity and mortality.
S. Tanwar, Freya A Rhodes, A. Srivastava, P. Trembling, W. Rosenberg   +4 more
semanticscholar   +1 more source

Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana, Angelico, Francesco, Baratta, Francesco, DEL BEN, Maria, Pastori, Daniele, Perri, Ludovica, Polimeni, Licia, Violi, Francesco   +7 more
core   +1 more source

Monocyte TREM-1 Levels Associate With Anti-TNF Responsiveness in IBD Through Autophagy and Fcγ-Receptor Signaling Pathways

Frontiers in Immunology, 2021
The expression of Triggering Receptor Expressed on Myeloid cells (TREM)-1 has been described as a predictive marker for anti-Tumor Necrosis Factor (TNF)-α monoclonal antibody (mAb) therapy responsiveness in patients with inflammatory bowel disease (IBD).
Marileen M. Prins, Bram Verstockt, Bram Verstockt, Marc Ferrante, Marc Ferrante, Séverine Vermeire, Séverine Vermeire, Manon E. Wildenberg, Manon E. Wildenberg, Pim J. Koelink   +9 more
doaj   +1 more source

Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

Signal Transduction and Targeted Therapy, 2020
As one of the bicyclic metabolic pathways of one-carbon metabolism, methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway.
Zhanghao Li, Feixia Wang, Baoyu Liang, Ying Su, Sumin Sun, Siwei Xia, Jiangjuan Shao, Zili Zhang, Min Hong, Feng Zhang, Shizhong Zheng   +10 more
semanticscholar   +1 more source