Results 111 to 120 of about 1,236,932 (359)

Role of Innate Lymphoid Cells in Lung Disease

Iranian Journal of Allergy, Asthma and Immunology, 2015
Innate lymphoid cells (ILCs) are identified as novel population of hematopoietic cells which protect the body by coordinating the innate immune response against a wide range of threats including infections, tissue damages and homeostatic disturbances ...
Sayed Mehran Marashian, Esmaeil Mortaz, Hamid Reza Jamaati, Mostafa Alavi-Moghaddam, Arda Kiani, Atefeh Abedini, Johan Garssen, Ian M.Adcock, Ali Akbar Velayati   +8 more
doaj  

Pulmonary Hypertension in Chronic Lung Diseases

Journal of the American College of Cardiology, 2013
Chronic obstructive lung disease (COPD) and diffuse parenchymal lung diseases (DPLD), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis, are associated with a high incidence of pulmonary hypertension (PH), which is linked with exercise limitation and a worse prognosis.
Seeger, Werner, Adir, Yochai, Albert Barbera, Joan, Champion, Hunter, Coghlan, John Gerard, Cottin, Vincent, de Marco, Teresa, Galiè, Nazzareno, Ghio, Stefano, Gibbs, Simon, Martinez, Fernando J., Semigran, Marc J., Simonneau, Gérald, Wells, Athol U., Vachiery, Jean-Luc   +14 more
openaire   +5 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Common mechanisms in chronic obstructive pulmonary disease and lung cancer

, 2021
HuiYang Zhou
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lung ultrasound for assessing disease progression in UIP and NSIP: a comparative study with HRCT and PFT/DLCO

BMC Pulmonary Medicine
Background This study aims to compare Lung Ultrasound (LUS) findings with High-Resolution Computerized Tomography (HRCT) and Pulmonary Function Tests (PFTs) to detect the severity of lung involvement in patients with Usual Interstitial Pneumonia (UIP ...
Nasrollahzadeh Milad, Idani Esmaeil, Abedini Atefeh, Malekshoaar Mehran, Sadeghi Mohsen, Kasravi Maryam, Tofighi Rozhin, Roostaei Ghazal, Kiani Arda   +8 more
doaj   +1 more source

Association between vitamin D deficiencies in sarcoidosis with disease activity, course of disease and stages of lung involvements [PDF]

Journal of Medical Biochemistry, 2018
Background: Despite negative association between 25hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis.
Kiani Arda, Abedini Atefeh, Adcock Ian M., Sadat-Mirenayat Maryam, Taghavi Kimia, Mortaz Esmaeil, Kazempour-Dizaji Mehdi   +6 more
doaj  

Chronic suppurative lung disease and bronchiectasis in children, adolescents and adults in Australia and New Zealand: TSANZ position statement summary [PDF]

, 2023
Keith Grimwood, Emma Kennedy, Maree Toombs, Paul J. Torzillo, Anne B. Chang   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Chronic interstitial lung disease in children

Jornal de Pediatria, 2007
Interstitial lung diseases (ILDs) in children constitute a heterogeneous group of rare diseases that have been described and classified according to experiences and research in adults. However, pediatric pulmonologists have observed that the clinical spectrum is broader in children than in adults, and that many of these disorders have different courses
Maria Aparecida S S, Paiva, Sandra M M, Amaral   +1 more
openaire   +3 more sources